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Ablation of TrkB signalling in CCK neurons results in hypercortisolism and obesity

Overview of attention for article published in Nature Communications, March 2014
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Title
Ablation of TrkB signalling in CCK neurons results in hypercortisolism and obesity
Published in
Nature Communications, March 2014
DOI 10.1038/ncomms4427
Pubmed ID
Authors

Mirjam Geibel, Sylvia Badurek, Jacqueline M. Horn, Chinnavuth Vatanashevanopakorn, Juraj Koudelka, Claudia M. Wunderlich, Hella S. Brönneke, F. Thomas Wunderlich, Liliana Minichiello

Abstract

Dysregulation of hypothalamic-pituitary-adrenal (HPA) axis activity leads to debilitating neuroendocrine or metabolic disorders such as Cushing's syndrome (CS). Glucocorticoids control HPA axis activity through negative feedback to the pituitary gland and the central nervous system (CNS). However, the cellular mechanisms involved are poorly understood, particularly in the CNS. Here we show that, in mice, selective loss of TrkB signalling in cholecystokinin (CCK)-GABAergic neurons induces glucocorticoid resistance, resulting in increased corticotrophin-releasing hormone expression, chronic hypercortisolism, adrenocortical hyperplasia, glucose intolerance and mature-onset obesity, reminiscent of the human CS phenotype. Interestingly, obesity is not due to hyperphagia or decreased energy expenditure, but is associated with increased de novo lipogenesis in the liver. Our study therefore identifies CCK neurons as a novel and critical cellular component of the HPA axis, and demonstrates the requirement of TrkB for the transmission of glucocorticoid signalling.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
United Kingdom 1 2%
Canada 1 2%
Mexico 1 2%
United States 1 2%
Unknown 51 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 30%
Researcher 10 18%
Student > Bachelor 5 9%
Student > Master 5 9%
Student > Doctoral Student 2 4%
Other 8 14%
Unknown 9 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 32%
Neuroscience 10 18%
Biochemistry, Genetics and Molecular Biology 4 7%
Medicine and Dentistry 4 7%
Psychology 2 4%
Other 4 7%
Unknown 14 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2017.
All research outputs
#13,910,921
of 22,747,498 outputs
Outputs from Nature Communications
#39,572
of 46,825 outputs
Outputs of similar age
#114,950
of 221,230 outputs
Outputs of similar age from Nature Communications
#361
of 467 outputs
Altmetric has tracked 22,747,498 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 46,825 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,230 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 467 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.