↓ Skip to main content

Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor

Overview of attention for article published in Nature Communications, July 2017
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
3 X users

Citations

dimensions_citation
60 Dimensions

Readers on

mendeley
67 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor
Published in
Nature Communications, July 2017
DOI 10.1038/ncomms16103
Pubmed ID
Authors

Deepanjan Panda, Puja Saha, Tania Das, Jyotirmayee Dash

Abstract

The development of small molecules is essential to modulate the cellular functions of biological targets in living system. Target Guided Synthesis (TGS) approaches have been used for the identification of potent small molecules for biological targets. We herein demonstrate an innovative example of TGS using DNA nano-templates that promote Huisgen cycloaddition from an array of azide and alkyne fragments. A G-quadruplex and a control duplex DNA nano-template have been prepared by assembling the DNA structures on gold-coated magnetic nanoparticles. The DNA nano-templates facilitate the regioselective formation of 1,4-substituted triazole products, which are easily isolated by magnetic decantation. The G-quadruplex nano-template can be easily recovered and reused for five reaction cycles. The major triazole product, generated by the G-quadruplex inhibits c-MYC expression by directly targeting the c-MYC promoter G-quadruplex. This work highlights that the nano-TGS approach may serve as a valuable strategy to generate target-selective ligands for drug discovery.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 67 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 16%
Researcher 10 15%
Student > Master 9 13%
Student > Bachelor 5 7%
Student > Doctoral Student 4 6%
Other 7 10%
Unknown 21 31%
Readers by discipline Count As %
Chemistry 17 25%
Biochemistry, Genetics and Molecular Biology 14 21%
Agricultural and Biological Sciences 5 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Medicine and Dentistry 3 4%
Other 1 1%
Unknown 24 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2021.
All research outputs
#1,282,501
of 22,988,380 outputs
Outputs from Nature Communications
#18,567
of 47,315 outputs
Outputs of similar age
#27,528
of 312,506 outputs
Outputs of similar age from Nature Communications
#412
of 926 outputs
Altmetric has tracked 22,988,380 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 47,315 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.9. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,506 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 926 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.