↓ Skip to main content

Palladium( II ) Complexes with N ‐Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity

Overview of attention for article published in Chemical Biology & Drug Design, May 2014
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
12 Dimensions

Readers on

mendeley
23 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Palladium( II ) Complexes with N ‐Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity
Published in
Chemical Biology & Drug Design, May 2014
DOI 10.1111/cbdd.12322
Pubmed ID
Authors

Nenad Filipović, Sonja Grubišić, Maja Jovanović, Marija Dulović, Ivanka Marković, Olivera Klisurić, Aleksandar Marinković, Dragana Mitić, Katarina Anđelković, Tamara Todorović

Abstract

Novel Pd(II) complex with N-heteroaromatic Schiff base ligand, derived from 8-quinolinecarboxaldehyde (q8a) and ethyl hydrazinoacetate (haOEt), was synthesized and characterized by analytical and spectroscopy methods. The structure of novel complex, as well as structures of its quinoline and pyridine analogues, was optimized by density functional theory calculations, and theoretical data show good agreement with experimental results. A cytotoxic action of the complexes was evaluated on cultures of human promyelocytic leukemia (HL-60), human glioma (U251), rat glioma (C6), and mouse fibrosarcoma (L929) cell lines. Among investigated compounds, only complexes with quinoline-based ligands reduce the cell numbers in a dose-dependent manner in investigated cell lines. The observed cytotoxic effect of two isomeric quinoline-based complexes is predominantly mediated through the induction of apoptotic cell death in HL-60 cell line. The cytotoxicity of most efficient novel Pd(II) complex is comparable to the activity of cisplatin, in all cell lines investigated.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 22%
Student > Ph. D. Student 4 17%
Researcher 4 17%
Student > Master 1 4%
Professor 1 4%
Other 1 4%
Unknown 7 30%
Readers by discipline Count As %
Chemistry 10 43%
Agricultural and Biological Sciences 2 9%
Energy 1 4%
Medicine and Dentistry 1 4%
Neuroscience 1 4%
Other 1 4%
Unknown 7 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2014.
All research outputs
#10,250,400
of 12,840,150 outputs
Outputs from Chemical Biology & Drug Design
#649
of 1,104 outputs
Outputs of similar age
#148,409
of 218,918 outputs
Outputs of similar age from Chemical Biology & Drug Design
#18
of 44 outputs
Altmetric has tracked 12,840,150 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,104 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 218,918 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.