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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Differential expression of HIF-1α in CD44+CD24-/low breast ductal carcinomas
|
|---|---|
| Published in |
Diagnostic Pathology, August 2011
|
| DOI | 10.1186/1746-1596-6-73 |
| Pubmed ID | |
| Authors |
João Paulo Oliveira-Costa, Juliana S Zanetti, Giórgia G Silveira, Danilo F Soave, Lucinei R Oliveira, Verônica A Zorgetto, Fernando A Soares, Sérgio Zucoloto, Alfredo Ribeiro-Silva |
| Abstract |
Cancer stem cell (CSC) hypothesis postulates that tumors are maintained by a self-renewing CSC population that is also capable of differentiating into non-self-renewing cell populations that constitute the bulk of tumor. Stem cells renewal and differentiation can be directly influenced by the oxygen levels of determined tissues, probably by the reduction of oxidative DNA damage in hypoxic regions, thus leading to a friendlier microenvironment, regarding to clonal expansion and for resistance to chemotherapeutic regimens. Furthermore, there have been strong data indicating a pivotal role of hypoxic niche in cancer stem cells development. There are evidence that hypoxia could drive the maintenance of CSC, via HIF-1α expression, but it still to be determined whether hypoxia markers are expressed in breast tumors presenting CD44+CD24-/low immunophenotype. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 2% |
| Unknown | 40 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 17% |
| Researcher | 7 | 17% |
| Student > Bachelor | 5 | 12% |
| Student > Postgraduate | 5 | 12% |
| Student > Ph. D. Student | 4 | 10% |
| Other | 8 | 20% |
| Unknown | 5 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 39% |
| Agricultural and Biological Sciences | 6 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 10% |
| Biochemistry, Genetics and Molecular Biology | 2 | 5% |
| Engineering | 2 | 5% |
| Other | 3 | 7% |
| Unknown | 8 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2011.
All research outputs
#18,293,967
of 22,649,029 outputs
Outputs from Diagnostic Pathology
#754
of 1,116 outputs
Outputs of similar age
#99,642
of 120,449 outputs
Outputs of similar age from Diagnostic Pathology
#5
of 7 outputs
Altmetric has tracked 22,649,029 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,116 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 120,449 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.