Title |
Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy study
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Published in |
BMC Cancer, March 2014
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DOI | 10.1186/1471-2407-14-189 |
Pubmed ID | |
Authors |
Lusik Cherkezyan, Yolanda Stypula-Cyrus, Hariharan Subramanian, Craig White, Mart Dela Cruz, Ramesh K Wali, Michael J Goldberg, Laura K Bianchi, Hemant K Roy, Vadim Backman |
Abstract |
Nuclear alterations are a well-known manifestation of cancer. However, little is known about the early, microscopically-undetectable stages of malignant transformation. Based on the phenomenon of field cancerization, the tissue in the field of a tumor can be used to identify and study the initiating events of carcinogenesis. Morphological changes in nuclear organization have been implicated in the field of colorectal cancer (CRC), and we hypothesize that characterization of chromatin alterations in the early stages of CRC will provide insight into cancer progression, as well as serve as a biomarker for early detection, risk stratification and prevention. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 1% |
Unknown | 78 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 25 | 32% |
Researcher | 11 | 14% |
Student > Bachelor | 8 | 10% |
Student > Doctoral Student | 6 | 8% |
Professor > Associate Professor | 5 | 6% |
Other | 12 | 15% |
Unknown | 12 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 18% |
Engineering | 14 | 18% |
Physics and Astronomy | 9 | 11% |
Biochemistry, Genetics and Molecular Biology | 7 | 9% |
Medicine and Dentistry | 6 | 8% |
Other | 12 | 15% |
Unknown | 17 | 22% |