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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Protective effects of acute exercise prior to doxorubicin on cardiac function of breast cancer patients: A proof-of-concept RCT
|
|---|---|
| Published in |
International Journal of Cardiology, July 2017
|
| DOI | 10.1016/j.ijcard.2017.07.037 |
| Pubmed ID | |
| Authors |
A.A. Kirkham, R.E. Shave, K.A. Bland, J.M. Bovard, N.D. Eves, K.A. Gelmon, D.C. McKenzie, S.A. Virani, E.J. Stöhr, D.E.R. Warburton, K.L. Campbell |
| Abstract |
Preclinical studies have reported that a single treadmill session performed 24h prior to doxorubicin provides cardio-protection. We aimed to characterize the acute change in cardiac function following an initial doxorubicin treatment in humans and determine whether an exercise session performed 24h prior to treatment changes this response. Breast cancer patients were randomized to either 30min of vigorous-intensity exercise 24h prior to the first doxorubicin treatment (n=13), or no vigorous exercise for 72h prior to treatment (control, n=11). Echocardiographically-derived left ventricular volumes, longitudinal strain, twist, E/A ratio, and circulating NT-proBNP, a marker of later cardiotoxicity, were measured before and 24-48h after the treatment. Following treatment in the control group, NT-proBNP, end-diastolic and stroke volumes, cardiac output, E/A ratio, strain, diastolic strain rate, twist, and untwist velocity significantly increased (all p≤0.01). Whereas systemic vascular resistance (p<0.01) decreased, and ejection fraction (p=0.02) and systolic strain rate (p<0.01) increased in the exercise group only. Relative to control, the exercise group had a significantly lower NT-proBNP (p<0.01) and a 46% risk reduction of exceeding the cut-point used to exclude acute heart failure. The first doxorubicin treatment is associated with acutely increased NT-proBNP, echocardiographic parameters of myocardial relaxation, left ventricular volume overload, and changes in longitudinal strain and twist opposite in direction to documented longer-term changes. An exercise session performed 24h prior to treatment attenuated NT-proBNP release and increased systolic function. Future investigations should verify these findings in a larger cohort and across multiple courses of doxorubicin. |
X Demographics
The data shown below were collected from the profiles of 37 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 8 | 22% |
| United Kingdom | 4 | 11% |
| Australia | 3 | 8% |
| Canada | 3 | 8% |
| United States | 2 | 5% |
| Ecuador | 2 | 5% |
| Luxembourg | 1 | 3% |
| Netherlands | 1 | 3% |
| Austria | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 12 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 28 | 76% |
| Scientists | 8 | 22% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 207 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 207 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 28 | 14% |
| Student > Bachelor | 26 | 13% |
| Student > Ph. D. Student | 19 | 9% |
| Researcher | 11 | 5% |
| Student > Postgraduate | 9 | 4% |
| Other | 43 | 21% |
| Unknown | 71 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 37 | 18% |
| Medicine and Dentistry | 32 | 15% |
| Sports and Recreations | 21 | 10% |
| Unspecified | 7 | 3% |
| Biochemistry, Genetics and Molecular Biology | 6 | 3% |
| Other | 18 | 9% |
| Unknown | 86 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2021.
All research outputs
#1,609,296
of 25,480,126 outputs
Outputs from International Journal of Cardiology
#279
of 7,532 outputs
Outputs of similar age
#30,880
of 324,919 outputs
Outputs of similar age from International Journal of Cardiology
#3
of 111 outputs
Altmetric has tracked 25,480,126 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,532 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,919 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 111 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.