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Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas

Overview of attention for article published in Cancer Research, August 2004
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

twitter
83 tweeters
patent
2 patents
facebook
693 Facebook pages
wikipedia
4 Wikipedia pages
googleplus
31 Google+ users
reddit
1 Redditor
video
5 video uploaders

Citations

dimensions_citation
185 Dimensions

Readers on

mendeley
180 Mendeley
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Title
Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas
Published in
Cancer Research, August 2004
DOI 10.1158/0008-5472.can-03-3927
Pubmed ID
Authors

Cristina Blázquez, Luis González-Feria, Luis Álvarez, Amador Haro, M. Llanos Casanova, Manuel Guzmán

Abstract

Cannabinoids inhibit tumor angiogenesis in mice, but the mechanism of their antiangiogenic action is still unknown. Because the vascular endothelial growth factor (VEGF) pathway plays a critical role in tumor angiogenesis, here we studied whether cannabinoids affect it. As a first approach, cDNA array analysis showed that cannabinoid administration to mice bearing s.c. gliomas lowered the expression of various VEGF pathway-related genes. The use of other methods (ELISA, Western blotting, and confocal microscopy) provided additional evidence that cannabinoids depressed the VEGF pathway by decreasing the production of VEGF and the activation of VEGF receptor (VEGFR)-2, the most prominent VEGF receptor, in cultured glioma cells and in mouse gliomas. Cannabinoid-induced inhibition of VEGF production and VEGFR-2 activation was abrogated both in vitro and in vivo by pharmacological blockade of ceramide biosynthesis. These changes in the VEGF pathway were paralleled by changes in tumor size. Moreover, intratumoral administration of the cannabinoid Delta9-tetrahydrocannabinol to two patients with glioblastoma multiforme (grade IV astrocytoma) decreased VEGF levels and VEGFR-2 activation in the tumors. Because blockade of the VEGF pathway constitutes one of the most promising antitumoral approaches currently available, the present findings provide a novel pharmacological target for cannabinoid-based therapies.

Twitter Demographics

The data shown below were collected from the profiles of 83 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 180 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
United Kingdom 1 <1%
Switzerland 1 <1%
Spain 1 <1%
Ukraine 1 <1%
Unknown 174 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 34 19%
Student > Master 29 16%
Student > Ph. D. Student 25 14%
Student > Bachelor 17 9%
Other 12 7%
Other 43 24%
Unknown 20 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 43 24%
Medicine and Dentistry 34 19%
Biochemistry, Genetics and Molecular Biology 25 14%
Pharmacology, Toxicology and Pharmaceutical Science 14 8%
Neuroscience 9 5%
Other 29 16%
Unknown 26 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 280. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2023.
All research outputs
#106,349
of 22,990,068 outputs
Outputs from Cancer Research
#52
of 17,945 outputs
Outputs of similar age
#53
of 46,914 outputs
Outputs of similar age from Cancer Research
#1
of 205 outputs
Altmetric has tracked 22,990,068 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,945 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 46,914 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 205 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.