Title |
Hmga2is required for canonical WNT signaling during lung development
|
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Published in |
BMC Biology, March 2014
|
DOI | 10.1186/1741-7007-12-21 |
Pubmed ID | |
Authors |
Indrabahadur Singh, Aditi Mehta, Adriana Contreras, Thomas Boettger, Gianni Carraro, Matthew Wheeler, Hector A Cabrera-Fuentes, Saverio Bellusci, Werner Seeger, Thomas Braun, Guillermo Barreto |
Abstract |
The high-mobility-group (HMG) proteins are the most abundant non-histone chromatin-associated proteins. HMG proteins are present at high levels in various undifferentiated tissues during embryonic development and their levels are strongly reduced in the corresponding adult tissues, where they have been implicated in maintaining and activating stem/progenitor cells. Here we deciphered the role of the high-mobility-group AT-hook protein 2 (HMGA2) during lung development by analyzing the lung of Hmga2-deficient mice (Hmga2(-/-)). |
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