Chapter title |
G Protein-Coupled Receptor Trafficking and Signalling in the Enteric Nervous System: The Past, Present and Future
|
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Chapter number | 14 |
Book title |
The Enteric Nervous System
|
Published in |
Advances in experimental medicine and biology, July 2016
|
DOI | 10.1007/978-3-319-27592-5_14 |
Pubmed ID | |
Book ISBNs |
978-3-31-927590-1, 978-3-31-927592-5
|
Authors |
Poole, Daniel P., Bunnett, Nigel W., Daniel P. Poole, Nigel W. Bunnett |
Abstract |
G protein-coupled receptors (GPCRs) enable cells to detect and respond to changes in their extracellular environment. With over 800 members, the GPCR family includes receptors for a diverse range of agonists including olfactants, neurotransmitters and hormones. Importantly, GPCRs represent a major therapeutic target, with approximately 50 % of all current drugs acting at some aspect of GPCR signalling (Audet and Bouvier 2008). GPCRs are widely expressed by all cell types in the gastrointestinal (GI) tract and are major regulators of every aspect of gut function. Many GPCRs are internalised upon activation, and this represents one of the mechanisms through which G protein-signalling is terminated. The latency between the endocytosis of GPCRs and their recycling and resensitization is a major determinant of the cell's ability to respond to subsequent exposure to agonists. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 8 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 38% |
Student > Bachelor | 1 | 13% |
Student > Doctoral Student | 1 | 13% |
Student > Ph. D. Student | 1 | 13% |
Professor | 1 | 13% |
Other | 0 | 0% |
Unknown | 1 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 38% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 13% |
Agricultural and Biological Sciences | 1 | 13% |
Medicine and Dentistry | 1 | 13% |
Unknown | 2 | 25% |