Chapter title |
Alzheimer’s Disease: Insights from Genetic Mouse Models and Current Advances in Human IPSC-Derived Neurons
|
---|---|
Chapter number | 1 |
Book title |
Neurodegenerative Diseases
|
Published in |
Advances in neurobiology, July 2017
|
DOI | 10.1007/978-3-319-57193-5_1 |
Pubmed ID | |
Book ISBNs |
978-3-31-957191-1, 978-3-31-957193-5
|
Authors |
Harasta, Anne E., Ittner, Lars M., Anne E. Harasta, Lars M. Ittner |
Abstract |
Alzheimer's disease was first described in 1906 and since then tremendous efforts have been made to fully understand the disease pathology and to find a cure for this neurodegenerative disease. The diagnosis of Alzheimer's is still difficult, especially in early stages of the disease. Current treatment of Alzheimer's only ameliorates the symptoms but fails to provide a therapy. Over the last decades, animal models have been proven valuable in elucidating insights of the pathology. In vitro models using patient-derived cells are currently emerging and hold great promise in understanding the disease pathophysiology. Here, we introduce the neurobiology and genetic features of Alzheimer's and describe what we have learned from studies employing mouse models and patient-derived induced pluripotent stem cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 23% |
Researcher | 2 | 15% |
Other | 1 | 8% |
Student > Master | 1 | 8% |
Student > Ph. D. Student | 1 | 8% |
Other | 0 | 0% |
Unknown | 5 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 15% |
Biochemistry, Genetics and Molecular Biology | 2 | 15% |
Psychology | 1 | 8% |
Neuroscience | 1 | 8% |
Engineering | 1 | 8% |
Other | 0 | 0% |
Unknown | 6 | 46% |