Chapter title |
Motoneuron Disease: Basic Science
|
---|---|
Chapter number | 6 |
Book title |
Neurodegenerative Diseases
|
Published in |
Advances in neurobiology, July 2017
|
DOI | 10.1007/978-3-319-57193-5_6 |
Pubmed ID | |
Book ISBNs |
978-3-31-957191-1, 978-3-31-957193-5
|
Authors |
Ilieva, Hristelina, Maragakis, Nicholas J., Hristelina Ilieva, Nicholas J. Maragakis |
Abstract |
ALS is a relentless neurodegenerative disease in which motor neurons are the susceptible neuronal population. Their death results in progressive paresis of voluntary and respiratory muscles. The unprecedented rate of discoveries over the last two decades have broadened our knowledge of genetic causes and helped delineate molecular pathways. Here we critically review ALS epidemiology, genetics, pathogenic mechanisms, available animal models, and iPS cell technologies with a focus on their translational therapeutic potential. Despite limited clinical success in treatments to date, the new discoveries detailed here offer new models for uncovering disease mechanisms as well as novel strategies for intervention. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 15% |
Student > Bachelor | 4 | 15% |
Student > Ph. D. Student | 4 | 15% |
Student > Postgraduate | 2 | 7% |
Lecturer | 1 | 4% |
Other | 4 | 15% |
Unknown | 8 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Nursing and Health Professions | 5 | 19% |
Medicine and Dentistry | 5 | 19% |
Biochemistry, Genetics and Molecular Biology | 4 | 15% |
Agricultural and Biological Sciences | 2 | 7% |
Neuroscience | 2 | 7% |
Other | 1 | 4% |
Unknown | 8 | 30% |