Chapter title |
Motoneuron Disease: Clinical
|
---|---|
Chapter number | 7 |
Book title |
Neurodegenerative Diseases
|
Published in |
Advances in neurobiology, July 2017
|
DOI | 10.1007/978-3-319-57193-5_7 |
Pubmed ID | |
Book ISBNs |
978-3-31-957191-1, 978-3-31-957193-5
|
Authors |
Ilieva, Hristelina, Maragakis, Nicholas J., Hristelina Ilieva, Nicholas J. Maragakis |
Abstract |
ALS is a neurodegenerative disease in which the primary symptoms result in progressive neuromuscular weakness. Recent studies have highlighted that there is significant heterogeneity with regard to anatomical and temporal disease progression. Importantly, more recent advances in genetics have revealed new causative genes to the disease. New efforts have focused on the development of biomarkers that could aid in diagnosis, prognosis, and serve as pharmacodynamics markers. Although traditional pharmaceuticals continue to undergo trials for ALS, new therapeutic strategies including stem cell transplantation studies, gene therapies, and antisense therapies targeting some of the familial forms of ALS are gaining momentum. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 78 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 13% |
Student > Master | 9 | 12% |
Student > Bachelor | 9 | 12% |
Student > Postgraduate | 8 | 10% |
Librarian | 4 | 5% |
Other | 9 | 12% |
Unknown | 29 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 29% |
Nursing and Health Professions | 7 | 9% |
Biochemistry, Genetics and Molecular Biology | 4 | 5% |
Social Sciences | 3 | 4% |
Immunology and Microbiology | 2 | 3% |
Other | 8 | 10% |
Unknown | 31 | 40% |