Chapter title |
Neurodegeneration and Pathology in Epilepsy: Clinical and Basic Perspectives
|
---|---|
Chapter number | 12 |
Book title |
Neurodegenerative Diseases
|
Published in |
Advances in neurobiology, July 2017
|
DOI | 10.1007/978-3-319-57193-5_12 |
Pubmed ID | |
Book ISBNs |
978-3-31-957191-1, 978-3-31-957193-5
|
Authors |
Farrell, Jordan S., Wolff, Marshal D., Teskey, G. Campbell, Jordan S. Farrell, Marshal D. Wolff, G. Campbell Teskey |
Abstract |
Epilepsy is commonly associated with a number of neurodegenerative and pathological alterations in those areas of the brain that are involved in repeated electrographic seizures. These most prominently include neuron loss and an increase in astrocyte number and size but may also include enhanced blood-brain barrier permeability, the formation of new capillaries, axonal sprouting, and central inflammation. In animal models in which seizures are either repeatedly elicited or are self-generated, a similar set of neurodegenerative and pathological alterations in brain anatomy are observed. The primary causal agent responsible for these alterations may be the cascade of events that follow a seizure and lead to an hypoperfusion/hypoxic episode. While epilepsy has long and correctly been considered an electrical disorder, the vascular system likely plays an important causal role in the neurodegeneration and pathology that occur as a consequence of repeated seizures. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 78 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 13% |
Student > Master | 10 | 13% |
Student > Bachelor | 9 | 12% |
Researcher | 6 | 8% |
Other | 5 | 6% |
Other | 10 | 13% |
Unknown | 28 | 36% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 13 | 17% |
Neuroscience | 11 | 14% |
Biochemistry, Genetics and Molecular Biology | 9 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Psychology | 3 | 4% |
Other | 8 | 10% |
Unknown | 30 | 38% |