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Effects of cytosine methylation on transcription factor binding sites

Overview of attention for article published in BMC Genomics, January 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
9 tweeters
googleplus
1 Google+ user

Citations

dimensions_citation
141 Dimensions

Readers on

mendeley
277 Mendeley
citeulike
1 CiteULike
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Title
Effects of cytosine methylation on transcription factor binding sites
Published in
BMC Genomics, January 2014
DOI 10.1186/1471-2164-15-119
Pubmed ID
Authors

Yulia A Medvedeva, Abdullah M Khamis, Ivan V Kulakovskiy, Wail Ba-Alawi, Md Shariful I Bhuyan, Hideya Kawaji, Timo Lassmann, Matthias Harbers, Alistair RR Forrest, Vladimir B Bajic

Abstract

DNA methylation in promoters is closely linked to downstream gene repression. However, whether DNA methylation is a cause or a consequence of gene repression remains an open question. If it is a cause, then DNA methylation may affect the affinity of transcription factors (TFs) for their binding sites (TFBSs). If it is a consequence, then gene repression caused by chromatin modification may be stabilized by DNA methylation. Until now, these two possibilities have been supported only by non-systematic evidence and they have not been tested on a wide range of TFs. An average promoter methylation is usually used in studies, whereas recent results suggested that methylation of individual cytosines can also be important.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 277 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
United Kingdom 3 1%
Netherlands 2 <1%
Norway 1 <1%
India 1 <1%
Belgium 1 <1%
Spain 1 <1%
Japan 1 <1%
Canada 1 <1%
Other 0 0%
Unknown 263 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 87 31%
Researcher 51 18%
Student > Master 36 13%
Student > Bachelor 31 11%
Student > Doctoral Student 17 6%
Other 38 14%
Unknown 17 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 134 48%
Biochemistry, Genetics and Molecular Biology 71 26%
Medicine and Dentistry 10 4%
Computer Science 8 3%
Engineering 4 1%
Other 19 7%
Unknown 31 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2018.
All research outputs
#3,540,647
of 14,207,018 outputs
Outputs from BMC Genomics
#1,823
of 8,337 outputs
Outputs of similar age
#44,234
of 191,003 outputs
Outputs of similar age from BMC Genomics
#4
of 8 outputs
Altmetric has tracked 14,207,018 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 8,337 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 191,003 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.