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Conditioned place preference behavior in zebrafish

Overview of attention for article published in Nature Protocols, February 2011
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Title
Conditioned place preference behavior in zebrafish
Published in
Nature Protocols, February 2011
DOI 10.1038/nprot.2010.201
Pubmed ID
Authors

Priya Mathur, Billy Lau, Su Guo

Abstract

This protocol describes conditioned place preference (CPP) in zebrafish following a single exposure to a substance. In the CPP paradigm, animals show a preference for an environment that has previously been associated with a substance (drug), thus indicating the positive-reinforcing qualities of that substance. The test tank consists of two visually distinct compartments separated by a central alley. The protocol involves three steps: the determination of initial preference, one conditioning session and the determination of final preference. This procedure is carried out in ∼2 d; other reported CPP protocols take up to 2 weeks. An increase in preference for the drug-associated compartment is observed after a single exposure. Establishment of this high-throughput protocol in zebrafish makes it possible to investigate the molecular and cellular basis of choice behavior, reward and associative learning. The protocol is also a tool for testing psychoactive compounds in the context of a vertebrate brain.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 161 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 4 2%
United Kingdom 2 1%
Brazil 2 1%
United States 2 1%
France 1 <1%
Chile 1 <1%
Canada 1 <1%
Germany 1 <1%
Spain 1 <1%
Other 1 <1%
Unknown 145 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 19%
Researcher 26 16%
Student > Master 25 16%
Student > Bachelor 14 9%
Student > Doctoral Student 14 9%
Other 27 17%
Unknown 25 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 56 35%
Neuroscience 18 11%
Biochemistry, Genetics and Molecular Biology 12 7%
Psychology 9 6%
Medicine and Dentistry 7 4%
Other 23 14%
Unknown 36 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2011.
All research outputs
#20,143,522
of 22,649,029 outputs
Outputs from Nature Protocols
#2,695
of 2,724 outputs
Outputs of similar age
#100,094
of 106,493 outputs
Outputs of similar age from Nature Protocols
#25
of 25 outputs
Altmetric has tracked 22,649,029 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,724 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 106,493 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.