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Mendeley readers
Attention Score in Context
| Title |
Archaic Hominin Introgression in Africa Contributes to Functional Salivary MUC7 Genetic Variation
|
|---|---|
| Published in |
Molecular Biology and Evolution, July 2017
|
| DOI | 10.1093/molbev/msx206 |
| Pubmed ID | |
| Authors |
Duo Xu, Pavlos Pavlidis, Recep Ozgur Taskent, Nikolaos Alachiotis, Colin Flanagan, Michael DeGiorgio, Ran Blekhman, Stefan Ruhl, Omer Gokcumen |
| Abstract |
One of the most abundant proteins in human saliva, mucin-7, is encoded by the MUC7 gene, which harbors copy number variable subexonic repeats (PTS-repeats) that affect the size and glycosylation potential of this protein. We recently documented the adaptive evolution of MUC7 subexonic copy number variation among primates. Yet, the evolution of MUC7 genetic variation in humans remained unexplored. Here, we found that PTS-repeat copy number variation has evolved recurrently in the human lineage, thereby generating multiple haplotypic backgrounds carrying five or six PTS-repeat copy number alleles. Contrary to previous studies, we found no associations between the copy number of PTS-repeats and protection against asthma. Instead, we revealed a significant association of MUC7 haplotypic variation with the composition of the oral microbiome. Furthermore, based on in-depth simulations, we conclude that a divergent MUC7 haplotype likely originated in an unknown African hominin population and introgressed into ancestors of modern Africans. |
X Demographics
The data shown below were collected from the profiles of 93 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 22 | 24% |
| United Kingdom | 6 | 6% |
| Spain | 4 | 4% |
| Mexico | 3 | 3% |
| Sweden | 2 | 2% |
| France | 2 | 2% |
| Australia | 1 | 1% |
| Chile | 1 | 1% |
| South Africa | 1 | 1% |
| Other | 6 | 6% |
| Unknown | 45 | 48% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 65 | 70% |
| Scientists | 28 | 30% |
Mendeley readers
The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 112 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 14% |
| Researcher | 16 | 14% |
| Student > Master | 14 | 13% |
| Student > Bachelor | 13 | 12% |
| Professor | 8 | 7% |
| Other | 20 | 18% |
| Unknown | 25 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 29% |
| Biochemistry, Genetics and Molecular Biology | 18 | 16% |
| Social Sciences | 7 | 6% |
| Arts and Humanities | 7 | 6% |
| Medicine and Dentistry | 4 | 4% |
| Other | 14 | 13% |
| Unknown | 29 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 540. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2024.
All research outputs
#46,153
of 26,017,215 outputs
Outputs from Molecular Biology and Evolution
#13
of 5,307 outputs
Outputs of similar age
#932
of 328,384 outputs
Outputs of similar age from Molecular Biology and Evolution
#1
of 58 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,307 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,384 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.