Title |
The Blockade of the Transient Receptor Potential Vanilloid Type 1 and Fatty Acid Amide Hydrolase Decreases Symptoms and Central Sequelae in the Medial Prefrontal Cortex of Neuropathic Rats
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Published in |
Molecular Pain, January 2011
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DOI | 10.1186/1744-8069-7-7 |
Pubmed ID | |
Authors |
Vito de Novellis, Daniela Vita, Luisa Gatta, Livio Luongo, Giulia Bellini, Maria De Chiaro, Ida Marabese, Dario Siniscalco, Serena Boccella, Fabiana Piscitelli, Vincenzo Di Marzo, Enza Palazzo, Francesco Rossi, Sabatino Maione |
Abstract |
Neuropathic pain is a chronic disease resulting from dysfunction within the "pain matrix". The basolateral amygdala (BLA) can modulate cortical functions and interactions between this structure and the medial prefrontal cortex (mPFC) are important for integrating emotionally salient information. In this study, we have investigated the involvement of the transient receptor potential vanilloid type 1 (TRPV1) and the catabolic enzyme fatty acid amide hydrolase (FAAH) in the morphofunctional changes occurring in the pre-limbic/infra-limbic (PL/IL) cortex in neuropathic rats. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 3% |
Japan | 1 | 1% |
Iran, Islamic Republic of | 1 | 1% |
Unknown | 72 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 24 | 32% |
Student > Bachelor | 8 | 11% |
Student > Ph. D. Student | 7 | 9% |
Professor | 6 | 8% |
Other | 6 | 8% |
Other | 18 | 24% |
Unknown | 7 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 20% |
Neuroscience | 14 | 18% |
Agricultural and Biological Sciences | 14 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
Biochemistry, Genetics and Molecular Biology | 5 | 7% |
Other | 11 | 14% |
Unknown | 11 | 14% |