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X Demographics
Mendeley readers
| Title |
Outcomes of Hematopoietic Cell Transplantation for Diffuse Large B Cell Lymphoma Transformed from Follicular Lymphoma
|
|---|---|
| Published in |
Transplantation and Cellular Therapy, March 2014
|
| DOI | 10.1016/j.bbmt.2014.03.014 |
| Pubmed ID | |
| Authors |
Baldeep Wirk, Timothy S. Fenske, Mehdi Hamadani, Mei-Jie Zhang, Zhen-Huan Hu, Görgün Akpek, Mahmoud D. Aljurf, Philippe Armand, Ernesto Ayala, Veronika Bachanova, Brian Bolwell, Mitchell S. Cairo, Amanda Cashen, Yi-Bin Chen, Luciano J. Costa, Shatha Farhan, César O. Freytes, James L. Gajewski, John Gibson, Gregory A. Hale, Leona A. Holmberg, Jack W. Hsu, David J. Inwards, Rummurti T. Kamble, Dipnarine Maharaj, Richard T. Maziarz, Reinhold Munker, Rajneesh Nath, Nishitha M. Reddy, Craig B. Reeder, David A. Rizzieri, Craig S. Sauter, Bipin N. Savani, Harry C. Schouten, Anna Sureda, Julie M. Vose, Edmund K. Waller, Peter H. Wiernik, Robert Peter Gale, Linda J. Burns, Wael Saber |
| Abstract |
There are limited data on the outcomes of autologous or allogeneic hematopoietic cell transplantation (HCT) in diffuse large B cell lymphoma transformed from follicular lymphoma. We analyzed transplantation outcomes in 141 subjects with biopsy-proven diffuse large B-cell lymphoma transformed from follicular lymphoma reported to the Center for International Blood and Marrow Transplant Research between 1990 and 2009. Two groups were identified: autologous HCT (auto-HCT; n = 108) and allogeneic HCT (allo-HCT; n = 33). Fewer auto-HCTs were done for transformed follicular lymphoma in 2003 to 2009, with a shift favoring allo-HCT. Auto-HCT was associated with a 1-year nonrelapse mortality (NRM) of 8% (95% confidence interval [CI], 4% to 14%), 5-year progression-free survival of 35% (95% CI, 26% to 45%), and 5-year overall survival of 50% (95% CI, 40% to 59%). In contrast, allo-HCT was associated with a 1-year NRM of 41% (95% CI, 23% to 58%), 5-year progression-free survival of 18% (95% CI, 6% to 35%), and 5-year overall survival of 22% (95% CI, 8% to 41%). Auto-HCT for transformed follicular lymphoma achieves sustained remission in a high proportion of subjects. The high NRM of allo-HCT offset any benefit that might be associated with this transplantation modality. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 80% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 60% |
| Members of the public | 1 | 20% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 59 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 10 | 17% |
| Student > Ph. D. Student | 8 | 14% |
| Researcher | 7 | 12% |
| Professor > Associate Professor | 5 | 8% |
| Student > Bachelor | 3 | 5% |
| Other | 11 | 19% |
| Unknown | 15 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 49% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Agricultural and Biological Sciences | 2 | 3% |
| Unspecified | 1 | 2% |
| Physics and Astronomy | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 19 | 32% |