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Mendeley readers
Attention Score in Context
| Title |
Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence
|
|---|---|
| Published in |
Molecular Neurodegeneration, June 2009
|
| DOI | 10.1186/1750-1326-4-27 |
| Pubmed ID | |
| Authors |
Dale E Bredesen |
| Abstract |
Extensive genetic, biochemical, and histological evidence has implicated the amyloid-beta peptide (Abeta) in Alzheimer's disease pathogenesis, and several mechanisms have been suggested, such as metal binding, reactive oxygen species production, and membrane pore formation. However, recent evidence argues for an additional role for signaling mediated by the amyloid precursor protein, APP, in part via the caspase cleavage of APP at aspartate 664. Here we review the effects and implications of this cleavage event, and propose a model of Alzheimer's disease that focuses on the critical nature of this cleavage and its downstream effects. |
Mendeley readers
The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Kazakhstan | 1 | <1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| India | 1 | <1% |
| Unknown | 116 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 19% |
| Student > Bachelor | 19 | 15% |
| Student > Master | 18 | 15% |
| Researcher | 13 | 11% |
| Other | 9 | 7% |
| Other | 19 | 15% |
| Unknown | 22 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 35 | 28% |
| Biochemistry, Genetics and Molecular Biology | 17 | 14% |
| Medicine and Dentistry | 16 | 13% |
| Neuroscience | 9 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 7% |
| Other | 13 | 11% |
| Unknown | 25 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2013.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from Molecular Neurodegeneration
#714
of 976 outputs
Outputs of similar age
#42,286
of 122,796 outputs
Outputs of similar age from Molecular Neurodegeneration
#3
of 4 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 976 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.6. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,796 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.