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Phase I clinical study of multiple epitope peptide vaccine combined with chemoradiation therapy in esophageal cancer patients

Overview of attention for article published in Journal of Translational Medicine, April 2014
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Title
Phase I clinical study of multiple epitope peptide vaccine combined with chemoradiation therapy in esophageal cancer patients
Published in
Journal of Translational Medicine, April 2014
DOI 10.1186/1479-5876-12-84
Pubmed ID
Authors

Hisae Iinuma, Ryoji Fukushima, Tsuyoshi Inaba, Junko Tamura, Taisuke Inoue, Etsushi Ogawa, Masahiro Horikawa, Yoshibumi Ikeda, Noriyuki Matsutani, Kazuyoshi Takeda, Koji Yoshida, Takuya Tsunoda, Tadashi Ikeda, Yusuke Nakamura, Kota Okinaga

Abstract

Chemoradiation therapy (CRT) has been widely used for unresectable esophageal squamous cell carcinoma (ESCC) patients. However, many patients develop local recurrence after CRT. In this study, we hypothesized that the immunotherapy by peptide vaccine may be effective for the eradication of minimal residual cancer cells after CRT. This study was conducted as a phase I clinical trial of multiple-peptide vaccine therapy combined with CRT on patients with unresectable ESCC.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 89 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 19 21%
Researcher 15 17%
Student > Ph. D. Student 15 17%
Student > Bachelor 11 12%
Student > Postgraduate 5 6%
Other 12 13%
Unknown 12 13%
Readers by discipline Count As %
Medicine and Dentistry 32 36%
Agricultural and Biological Sciences 11 12%
Biochemistry, Genetics and Molecular Biology 7 8%
Immunology and Microbiology 5 6%
Nursing and Health Professions 3 3%
Other 17 19%
Unknown 14 16%