Title |
Phase I clinical study of multiple epitope peptide vaccine combined with chemoradiation therapy in esophageal cancer patients
|
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Published in |
Journal of Translational Medicine, April 2014
|
DOI | 10.1186/1479-5876-12-84 |
Pubmed ID | |
Authors |
Hisae Iinuma, Ryoji Fukushima, Tsuyoshi Inaba, Junko Tamura, Taisuke Inoue, Etsushi Ogawa, Masahiro Horikawa, Yoshibumi Ikeda, Noriyuki Matsutani, Kazuyoshi Takeda, Koji Yoshida, Takuya Tsunoda, Tadashi Ikeda, Yusuke Nakamura, Kota Okinaga |
Abstract |
Chemoradiation therapy (CRT) has been widely used for unresectable esophageal squamous cell carcinoma (ESCC) patients. However, many patients develop local recurrence after CRT. In this study, we hypothesized that the immunotherapy by peptide vaccine may be effective for the eradication of minimal residual cancer cells after CRT. This study was conducted as a phase I clinical trial of multiple-peptide vaccine therapy combined with CRT on patients with unresectable ESCC. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 89 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 19 | 21% |
Researcher | 15 | 17% |
Student > Ph. D. Student | 15 | 17% |
Student > Bachelor | 11 | 12% |
Student > Postgraduate | 5 | 6% |
Other | 12 | 13% |
Unknown | 12 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 32 | 36% |
Agricultural and Biological Sciences | 11 | 12% |
Biochemistry, Genetics and Molecular Biology | 7 | 8% |
Immunology and Microbiology | 5 | 6% |
Nursing and Health Professions | 3 | 3% |
Other | 17 | 19% |
Unknown | 14 | 16% |