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Fatal pulmonary embolism following splenectomy in a patient with Evan’s syndrome: case report and review of the literature

Overview of attention for article published in Thrombosis Journal, July 2017
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2 tweeters
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1 Facebook page

Citations

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2 Dimensions

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12 Mendeley
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Title
Fatal pulmonary embolism following splenectomy in a patient with Evan’s syndrome: case report and review of the literature
Published in
Thrombosis Journal, July 2017
DOI 10.1186/s12959-017-0141-5
Pubmed ID
Authors

Varun Monga, Seth M. Maliske, Usha Perepu

Abstract

Evans syndrome (ES) is a rare disease characterized by simultaneous or sequential development of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP) with or without immune neutropenia. Splenectomy is one of the treatment options for disease refractory to medical therapy. Venous thromboembolism (VTE) following splenectomy for hematological diseases has an incidence of 10%. Here we describe a case report of a young patient hospitalized with severe hemolytic anemia with Hgb 4.8 g/dl. He developed thrombocytopenia with platelet nadir of 52,000/mm(3), thus formally diagnosed with ES. He failed standard medical therapy. He underwent splenectomy and had a fatal outcome. Autopsy confirmed the cause of death as pulmonary embolism (PE). This case report and review of the literature highlight important aspects of the association between VTE, splenectomy, and hemolytic syndromes including the presence of thrombocytopenia. The burden of the disease is reviewed as well as various pathophysiologic mechanisms contributing to thromboembolic events in these patients and current perioperative prophylactic anticoagulation strategies. Despite an advancing body of literature increasing awareness of VTE following splenectomy, morbidity and mortality remains high. Identifying high risk individuals for thromboembolic complications from splenectomy remains a challenge. There are no consensus guidelines for proper perioperative and post-operative anti-coagulation. We encourage future research to determine which factors might be playing a role in increasing the risk for VTE in real time with hope of forming a consensus to guide management.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 17%
Student > Bachelor 2 17%
Student > Master 2 17%
Student > Doctoral Student 2 17%
Student > Postgraduate 2 17%
Other 2 17%
Readers by discipline Count As %
Medicine and Dentistry 6 50%
Immunology and Microbiology 2 17%
Biochemistry, Genetics and Molecular Biology 1 8%
Unspecified 1 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Other 1 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2017.
All research outputs
#6,897,845
of 11,530,102 outputs
Outputs from Thrombosis Journal
#90
of 142 outputs
Outputs of similar age
#138,739
of 262,833 outputs
Outputs of similar age from Thrombosis Journal
#4
of 8 outputs
Altmetric has tracked 11,530,102 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 142 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.1. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,833 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.