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Enhanced neural cell adhesion and neurite outgrowth on graphene-based biomimetic substrates.

Overview of attention for article published in BioMed Research International, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

news
1 news outlet

Citations

dimensions_citation
33 Dimensions

Readers on

mendeley
53 Mendeley
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Title
Enhanced neural cell adhesion and neurite outgrowth on graphene-based biomimetic substrates.
Published in
BioMed Research International, January 2014
DOI 10.1155/2014/212149
Pubmed ID
Authors

Hong SW, Lee JH, Kang SH, Hwang EY, Hwang YS, Lee MH, Han DW, Park JC, Hong, Suck Won

Abstract

Neural cell adhesion and neurite outgrowth were examined on graphene-based biomimetic substrates. The biocompatibility of carbon nanomaterials such as graphene and carbon nanotubes (CNTs), that is, single-walled and multiwalled CNTs, against pheochromocytoma-derived PC-12 neural cells was also evaluated by quantifying metabolic activity (with WST-8 assay), intracellular oxidative stress (with ROS assay), and membrane integrity (with LDH assay). Graphene films were grown by using chemical vapor deposition and were then coated onto glass coverslips by using the scooping method. Graphene sheets were patterned on SiO2/Si substrates by using photolithography and were then covered with serum for a neural cell culture. Both types of CNTs induced significant dose-dependent decreases in the viability of PC-12 cells, whereas graphene exerted adverse effects on the neural cells just at over 62.5 ppm. This result implies that graphene and CNTs, even though they were the same carbon-based nanomaterials, show differential influences on neural cells. Furthermore, graphene-coated or graphene-patterned substrates were shown to substantially enhance the adhesion and neurite outgrowth of PC-12 cells. These results suggest that graphene-based substrates as biomimetic cues have good biocompatibility as well as a unique surface property that can enhance the neural cells, which would open up enormous opportunities in neural regeneration and nanomedicine.

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
France 1 2%
Turkey 1 2%
Unknown 49 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 28%
Researcher 7 13%
Unspecified 7 13%
Student > Master 7 13%
Student > Bachelor 6 11%
Other 11 21%
Readers by discipline Count As %
Engineering 12 23%
Unspecified 9 17%
Materials Science 9 17%
Agricultural and Biological Sciences 7 13%
Medicine and Dentistry 5 9%
Other 11 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2016.
All research outputs
#1,067,403
of 7,724,913 outputs
Outputs from BioMed Research International
#313
of 4,160 outputs
Outputs of similar age
#27,480
of 175,583 outputs
Outputs of similar age from BioMed Research International
#16
of 175 outputs
Altmetric has tracked 7,724,913 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,160 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 175,583 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 175 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.