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Antinuclear antibodies defining autoimmunity pathways

Overview of attention for article published in Arthritis Research & Therapy, January 2014
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1 tweeter

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16 Mendeley
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Title
Antinuclear antibodies defining autoimmunity pathways
Published in
Arthritis Research & Therapy, January 2014
DOI 10.1186/ar4482
Pubmed ID
Authors

Eng M Tan

Abstract

Immunofluorescent imaging has been a powerful technique in helping to identify intracellular nuclear and cytoplasmic molecules which are target antigens of autoantibodies in systemic autoimmune disorders. Patterns of staining can be correlated with molecules engaged in specific cellular functions and distributed in distinct cellular domains. Different autoimmune disorders have different profiles of autoantibodies, and immunodiagnostics has become an important adjunct in differential diagnosis. An important finding that has eluded explanation is the presence of autoantibodies to many different antigens, manifested strikingly in systemic lupus erythematosus. In cancer, the occurrence of autoantibodies to tumor-associated antigens is not uncommon and a characteristic feature is also the presence of multiple autoantibodies. The targeted tumor-associated antigens are either oncogene or tumor suppressor gene products or their coactivators, which are altered or mutated and driving the autoimmune response. Most cancer cells have between two and eight mutated genes before oncogenic transformation occurs, initiating a process called synthetic lethality in tumorigenesis pathways. These observations beg the question of whether there are similar mechanisms in systemic lupus erythematosus and other disorders driving autoimmunity pathways. Targeting molecules that are synthetic lethal to each other is in the forefront of the search for anticancer therapy, and this could also be an objective in systemic autoimmune disorders.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 25%
Other 3 19%
Student > Bachelor 3 19%
Student > Ph. D. Student 2 13%
Unspecified 1 6%
Other 2 13%
Unknown 1 6%
Readers by discipline Count As %
Medicine and Dentistry 6 38%
Agricultural and Biological Sciences 2 13%
Immunology and Microbiology 2 13%
Mathematics 1 6%
Unspecified 1 6%
Other 1 6%
Unknown 3 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2014.
All research outputs
#3,060,896
of 4,507,509 outputs
Outputs from Arthritis Research & Therapy
#800
of 1,080 outputs
Outputs of similar age
#72,808
of 107,083 outputs
Outputs of similar age from Arthritis Research & Therapy
#30
of 40 outputs
Altmetric has tracked 4,507,509 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,080 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.