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Effects of artichoke (Cynara scolymus) leaf and bloom head extracts on chemically induced DNA lesions in Drosophila melanogaster

Overview of attention for article published in Genetics and Molecular Biology, February 2013
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Title
Effects of artichoke (Cynara scolymus) leaf and bloom head extracts on chemically induced DNA lesions in Drosophila melanogaster
Published in
Genetics and Molecular Biology, February 2013
DOI 10.1590/s1415-47572014000100015
Pubmed ID
Authors

Laura Vicedo Jacociunas, Rafael Rodrigues Dihl, Mauricio Lehmann, Alexandre de Barros Falcão Ferraz, Marc François Richter, Juliana da Silva, Heloísa Helena Rodrigues de Andrade

Abstract

The genotoxicity of bloom head (BHE) and leaf (LE) extracts from artichoke (Cynara scolymus L.), and their ability to modulate the mutagenicity and recombinogenicity of two alkylating agents (ethyl methanesulfonate - EMS and mitomycin C - MMC) and the intercalating agent bleomycin (BLM), were examined using the somatic mutation and recombination test (SMART) in Drosophila melanogaster. Neither the mutagenicity nor the recombinogenicity of BLM or MMC was modified by co- or post-treatment with BHE or LE. In contrast, co-treatment with BHE significantly enhanced the EMS-induced genotoxicity involving mutagenic and/or recombinant events. Co-treatment with LE did not alter the genotoxicity of EMS whereas post-treatment with the highest dose of LE significantly increased this genotoxicity. This enhancement included a synergistic increase restricted to somatic recombination. These results show that artichoke extracts promote homologous recombination in proliferative cells of D. melanogaster.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 21%
Student > Master 5 17%
Student > Ph. D. Student 4 14%
Other 3 10%
Student > Doctoral Student 2 7%
Other 6 21%
Unknown 3 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 24%
Biochemistry, Genetics and Molecular Biology 5 17%
Pharmacology, Toxicology and Pharmaceutical Science 3 10%
Medicine and Dentistry 3 10%
Engineering 3 10%
Other 3 10%
Unknown 5 17%