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Mendeley readers
Attention Score in Context
| Title |
Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells
|
|---|---|
| Published in |
BMC Cancer, December 2013
|
| DOI | 10.1186/1471-2407-13-574 |
| Pubmed ID | |
| Authors |
Maximilian Linxweiler, Stefan Schorr, Nico Schäuble, Martin Jung, Johannes Linxweiler, Frank Langer, Hans-Joachim Schäfers, Adolfo Cavalié, Richard Zimmermann, Markus Greiner |
| Abstract |
Tumor cells benefit from their ability to avoid apoptosis and invade other tissues. The endoplasmic reticulum (ER) membrane protein Sec62 is a key player in these processes. Sec62 is essential for cell migration and protects tumor cells against thapsigargin-induced ER stress, which are both linked to cytosolic Ca²⁺. SEC62 silencing leads to elevated cytosolic Ca²⁺ and increased ER Ca²⁺ leakage after thapsigargin treatment. Sec62 protein levels are significantly increased in different tumors, including prostate, lung and thyroid cancer. |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 47 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 19% |
| Student > Ph. D. Student | 9 | 19% |
| Student > Bachelor | 7 | 15% |
| Student > Master | 6 | 13% |
| Other | 5 | 10% |
| Other | 6 | 13% |
| Unknown | 6 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 25% |
| Biochemistry, Genetics and Molecular Biology | 10 | 21% |
| Medicine and Dentistry | 8 | 17% |
| Engineering | 2 | 4% |
| Environmental Science | 1 | 2% |
| Other | 4 | 8% |
| Unknown | 11 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2014.
All research outputs
#1,786,137
of 22,751,628 outputs
Outputs from BMC Cancer
#275
of 8,273 outputs
Outputs of similar age
#21,628
of 306,821 outputs
Outputs of similar age from BMC Cancer
#3
of 107 outputs
Altmetric has tracked 22,751,628 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,273 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,821 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 107 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.