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Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma

Overview of attention for article published in Cancer Research, August 2017
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

Mentioned by

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6 tweeters

Citations

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24 Dimensions

Readers on

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51 Mendeley
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Title
Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma
Published in
Cancer Research, August 2017
DOI 10.1158/0008-5472.can-17-0190
Pubmed ID
Authors

Barbara Rivera, Massimo Di Iorio, Jessica Frankum, Javad Nadaf, Somayyeh Fahiminiya, Suzanna L. Arcand, David L. Burk, Damien Grapton, Eva Tomiak, Valerie Hastings, Nancy Hamel, Rabea Wagener, Olga Aleynikova, Sylvie Giroux, Fadi F. Hamdan, Alexandre Dionne-Laporte, George Zogopoulos, Francois Rousseau, Albert M. Berghuis, Diane Provencher, Guy A. Rouleau, Jacques L. Michaud, Anne-Marie Mes-Masson, Jacek Majewski, Susanne Bens, Reiner Siebert, Steven A. Narod, Mohammad R. Akbari, Christopher J. Lord, Patricia N. Tonin, Alexandre Orthwein, William D. Foulkes

Abstract

RAD51D is a key player in DNA repair by homologous recombination (HR) and RAD51D truncating mutation carriers have an increased risk for ovarian cancer (OC). However, the contribution of non-truncating RAD51D variants to cancer predisposition remains uncertain. Using deep sequencing and case-control genotyping studies, we show that in French Canadians, the missense RAD51D variant c.620C>T;p.S207L is highly prevalent and is associated with a high risk for ovarian high-grade serous carcinoma (HGSC) (3.8% cases vs 0.2% controls). The frequency of the p.S207L variant did not significantly differ from that of controls in breast, endometrial, pancreas or colorectal adenocarcinomas. Functionally, we show for the first time that this mutation impairs HR by disrupting the RAD51D-XRCC2 interaction and confers PARP-inhibitor sensitivity. These results highlight the importance of a functional RAD51D-XRCC2 interaction to promote HR and prevent the development of HGSC. This study identifies c.620C>T;p.S207L as the first bona fide pathogenic RAD51D missense cancer susceptibility allele and supports the use of targeted PARP-inhibitor therapies in OC patients carrying deleterious missense RAD51D mutations.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 51 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 18%
Student > Ph. D. Student 8 16%
Student > Bachelor 7 14%
Student > Master 6 12%
Other 3 6%
Other 6 12%
Unknown 12 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 19 37%
Medicine and Dentistry 7 14%
Agricultural and Biological Sciences 7 14%
Chemical Engineering 1 2%
Business, Management and Accounting 1 2%
Other 2 4%
Unknown 14 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2022.
All research outputs
#6,209,951
of 22,818,766 outputs
Outputs from Cancer Research
#6,604
of 17,872 outputs
Outputs of similar age
#99,381
of 317,069 outputs
Outputs of similar age from Cancer Research
#137
of 451 outputs
Altmetric has tracked 22,818,766 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 17,872 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,069 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 451 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.