@Aging_Scientist @ArtemyShumskiy @MaxUnfried @SsJankauskas @Nature I think there are hundreds of papers about it. This review, "Replicative DNA polymerase mutations in cancer" is from 2014. For mice, much work started in the 1990's, but I don't remember t
@ArtirKel In humans germline variants in that poly are assoc. with cancer (colorectal and endometrial mainly) https://t.co/Np4l9emJj4
"A variety of in vitro studies has shown that proofreading improves replication fidelity approximately 100-fold." https://t.co/Hm5YuuFPJP
Pol δ and Pol ɛ error rate "of the order of 10(-7) substitution mutations per base." https://t.co/Hm5YuuFPJP