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Loss of Histone H4K20 Trimethylation Occurs in Preneoplasia and Influences Prognosis of Non–Small Cell Lung Cancer

Overview of attention for article published in Clinical Cancer Research, November 2008
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  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
1 blog

Citations

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185 Dimensions

Readers on

mendeley
106 Mendeley

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Title
Loss of Histone H4K20 Trimethylation Occurs in Preneoplasia and Influences Prognosis of Non–Small Cell Lung Cancer
Published in
Clinical Cancer Research, November 2008
DOI 10.1158/1078-0432.ccr-08-0869
Pubmed ID
18974389
Authors

Arnaud Van Den Broeck, Elisabeth Brambilla, Denis Moro-Sibilot, Sylvie Lantuejoul, Christian Brambilla, Beatrice Eymin, Saadi Khochbin, Sylvie Gazzeri

Abstract

Epigenetic modifications of histone have crucial roles in the control of gene activity, nuclear architecture, and genomic stability. In this respect, they may contribute to the development and progression of cancer. We investigated whether epigenetic changes of histone H4 are involved in lung carcinogenesis. Epigenetic modifications of histone H4 were studied by immunohistochemistry in normal lung and 157 lung carcinoma using antibodies specifically recognizing the acetylated (Ac) lysines 5 (K5), K8, K12, K16, and trimethylated (me3) K20 residues of histone H4. Western blotting was used to validate the immunohistochemistry results. H4K20me3 was also studied in 17 preneoplastic lesions. Expression of the Suv4-20h1/2 trimethyltransferases was analyzed by quantitative reverse transcription-PCR in a subset of tumor samples. As compared with normal lung, cancer cells displayed an aberrant pattern of histone H4 modifications with hyperacetylation of H4K5/H4K8, hypoacetylation of H4K12/H4K16, and loss of H4K20 trimethylation. Alteration of H4K20 trimethylation was frequent in squamous cell carcinoma (67%) and was observed in early precursors lesions in which the level of H4K20me3 staining strongly decreased with disease progression. In adenocarcinoma, the down-regulation of H4K20me3 was less frequent (28%) but allowed the identification of a subgroup of stage I adenocarcinoma patients with reduced survival (P = 0.007). Loss of H4K20 trimethylation was associated with decreased expression of Suv4-20h2, a specific H4K20 trimethyltransferase involved in telomere length maintenance. Our findings indicate an important role of histone H4 modifications in bronchial carcinogenesis and highlight H4K20me3 as a candidate biomarker for early detection of and therapeutic approaches to lung cancer.

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Mendeley readers

The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Unknown 105 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 25%
Researcher 13 12%
Student > Master 13 12%
Student > Bachelor 7 7%
Student > Postgraduate 7 7%
Other 15 14%
Unknown 24 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 28 26%
Agricultural and Biological Sciences 27 25%
Medicine and Dentistry 15 14%
Chemistry 6 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 3 3%
Unknown 24 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2023.
All research outputs
#5,920,098
of 23,392,375 outputs
Outputs from Clinical Cancer Research
#5,649
of 12,725 outputs
Outputs of similar age
#25,757
of 89,082 outputs
Outputs of similar age from Clinical Cancer Research
#92
of 170 outputs
Altmetric has tracked 23,392,375 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 12,725 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.2. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 89,082 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 170 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.

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