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Current Advances in Retroviral Gene Therapy

Overview of attention for article published in Current Gene Therapy, June 2011
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#4 of 325)
  • High Attention Score compared to outputs of the same age (95th percentile)

Mentioned by

blogs
2 blogs
twitter
6 tweeters
patent
52 patents

Citations

dimensions_citation
71 Dimensions

Readers on

mendeley
197 Mendeley
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Title
Current Advances in Retroviral Gene Therapy
Published in
Current Gene Therapy, June 2011
DOI 10.2174/156652311795684740
Pubmed ID
Authors

Youngsuk Yi, Moon Jong Noh, Kwan Hee Lee

Abstract

There have been major changes since the incidents of leukemia development in X-SCID patients after the treatments using retroviral gene therapy. Due to the risk of oncogenesis caused by retroviral insertional activation of host genes, most of the efforts focused on the lentiviral therapies. However, a relative clonal dominance was detected in a patient with β-thalassemia Major, two years after the subject received genetically modified hematopoietic stem cells using lentiviral vectors. This disappointing result of the recent clinical trial using lentiviral vector tells us that the current and most advanced vector systems does not have enough safety. In this review, various safety features that have been tried for the retroviral gene therapy are introduced and the possible new ways of improvements are discussed. Additional feature of chromatin insulators, co-transduction of a suicidal gene under the control of an inducible promoter, conditional expression of the transgene only in appropriate target cells, targeted transduction, cell type-specific expression, targeted local administration, splitting of the viral genome, and site specific insertion of retroviral vector are discussed here.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 197 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 3 2%
United Kingdom 2 1%
Russia 2 1%
South Africa 1 <1%
Spain 1 <1%
Indonesia 1 <1%
Sri Lanka 1 <1%
United States 1 <1%
Netherlands 1 <1%
Other 0 0%
Unknown 184 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 52 26%
Student > Bachelor 39 20%
Student > Master 38 19%
Researcher 18 9%
Student > Postgraduate 14 7%
Other 36 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 81 41%
Medicine and Dentistry 40 20%
Biochemistry, Genetics and Molecular Biology 37 19%
Unspecified 13 7%
Chemistry 8 4%
Other 18 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2018.
All research outputs
#541,939
of 13,698,995 outputs
Outputs from Current Gene Therapy
#4
of 325 outputs
Outputs of similar age
#8,987
of 190,721 outputs
Outputs of similar age from Current Gene Therapy
#1
of 3 outputs
Altmetric has tracked 13,698,995 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 325 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 190,721 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them