Title |
Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence
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Published in |
Retrovirology, June 2011
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DOI | 10.1186/1742-4690-8-44 |
Pubmed ID | |
Authors |
Hong Na, Shaona Acharjee, Gareth Jones, Pornpun Vivithanaporn, Farshid Noorbakhsh, Nicola McFarlane, Ferdinand Maingat, Klaus Ballanyi, Carlos A Pardo, Éric A Cohen, Christopher Power |
Abstract |
Viral diversity and abundance are defining properties of human immunodeficiency virus (HIV)-1's biology and pathogenicity. Despite the increasing availability of antiretroviral therapy, HIV-associated dementia (HAD) continues to be a devastating consequence of HIV-1 infection of the brain although the underlying disease mechanisms remain uncertain. Herein, molecular diversity within the HIV-1 non-structural gene, Vpr, was examined in RNA sequences derived from brain and blood of HIV/AIDS patients with or without HIV-associated dementia (HAD) together with the ensuing pathobiological effects. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 18% |
United States | 3 | 14% |
Australia | 1 | 5% |
Italy | 1 | 5% |
Canada | 1 | 5% |
Ireland | 1 | 5% |
Israel | 1 | 5% |
Germany | 1 | 5% |
Unknown | 9 | 41% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 18 | 82% |
Practitioners (doctors, other healthcare professionals) | 3 | 14% |
Scientists | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 2 | 5% |
Spain | 1 | 2% |
Unknown | 40 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 23% |
Student > Master | 7 | 16% |
Student > Ph. D. Student | 6 | 14% |
Student > Postgraduate | 4 | 9% |
Student > Bachelor | 3 | 7% |
Other | 7 | 16% |
Unknown | 6 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 30% |
Medicine and Dentistry | 11 | 26% |
Neuroscience | 5 | 12% |
Nursing and Health Professions | 2 | 5% |
Psychology | 2 | 5% |
Other | 4 | 9% |
Unknown | 6 | 14% |