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G4-Tetra DNA Duplex Induce Lung Cancer Cell Apoptosis in A549 Cells

Overview of attention for article published in Discover Nano, October 2016
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Title
G4-Tetra DNA Duplex Induce Lung Cancer Cell Apoptosis in A549 Cells
Published in
Discover Nano, October 2016
DOI 10.1186/s11671-016-1652-x
Pubmed ID
Authors

Xiaobo Xu, YiZhuo Zhao, Hu Lu, Cuiping Fu, Xiao Li, Liyan Jiang, Shanqun Li

Abstract

The specific DNA is typically impermeable to the plasma membrane due to its natural characters, but DNA tetra structures (DTNs) can be readily uptake by cells in the absence of transfection agents, providing a new strategy to deliver DNA drugs. In this research, the delivery efficiency of tetrahedral DNA nanostructures was measured on adenocarcinomic human alveolar basal epithelial (A549) cells via delivering AS1411 (G4). The DNA tetra-AS1411 complex was rapidly and abundantly uptake by A549 cells, and the induced apoptosis was enhanced. Furthermore, biodistribution in mouse proved the rapid clearance from non-targeted organs in vivo. This study improved the understanding of potential function in DNA-based drug delivery and proved that DTNs-AS1411 could be potentially useful for the treatment of lung cancer.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 21%
Student > Ph. D. Student 2 14%
Researcher 2 14%
Student > Master 2 14%
Professor 1 7%
Other 2 14%
Unknown 2 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 36%
Chemistry 2 14%
Agricultural and Biological Sciences 1 7%
Unspecified 1 7%
Medicine and Dentistry 1 7%
Other 1 7%
Unknown 3 21%