↓ Skip to main content

The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

Overview of attention for article published in Nature Genetics, April 2014
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Citations

dimensions_citation
464 Dimensions

Readers on

mendeley
398 Mendeley
citeulike
2 CiteULike
Title
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
Published in
Nature Genetics, April 2014
DOI 10.1038/ng.2938
Pubmed ID
Abstract

Pediatric high-grade glioma (HGG) is a devastating disease with a less than 20% survival rate 2 years after diagnosis. We analyzed 127 pediatric HGGs, including diffuse intrinsic pontine gliomas (DIPGs) and non-brainstem HGGs (NBS-HGGs), by whole-genome, whole-exome and/or transcriptome sequencing. We identified recurrent somatic mutations in ACVR1 exclusively in DIPGs (32%), in addition to previously reported frequent somatic mutations in histone H3 genes, TP53 and ATRX, in both DIPGs and NBS-HGGs. Structural variants generating fusion genes were found in 47% of DIPGs and NBS-HGGs, with recurrent fusions involving the neurotrophin receptor genes NTRK1, NTRK2 and NTRK3 in 40% of NBS-HGGs in infants. Mutations targeting receptor tyrosine kinase-RAS-PI3K signaling, histone modification or chromatin remodeling, and cell cycle regulation were found in 68%, 73% and 59% of pediatric HGGs, respectively, including in DIPGs and NBS-HGGs. This comprehensive analysis provides insights into the unique and shared pathways driving pediatric HGG within and outside the brainstem.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 398 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 2%
France 2 <1%
Netherlands 2 <1%
Germany 2 <1%
Japan 2 <1%
Spain 2 <1%
United Kingdom 2 <1%
Sweden 1 <1%
Belgium 1 <1%
Other 3 <1%
Unknown 375 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 91 23%
Researcher 91 23%
Other 37 9%
Student > Bachelor 33 8%
Student > Postgraduate 29 7%
Other 82 21%
Unknown 35 9%
Readers by discipline Count As %
Medicine and Dentistry 116 29%
Agricultural and Biological Sciences 99 25%
Biochemistry, Genetics and Molecular Biology 83 21%
Neuroscience 18 5%
Pharmacology, Toxicology and Pharmaceutical Science 10 3%
Other 27 7%
Unknown 45 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 380. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2019.
All research outputs
#27,820
of 13,420,122 outputs
Outputs from Nature Genetics
#68
of 6,195 outputs
Outputs of similar age
#373
of 190,107 outputs
Outputs of similar age from Nature Genetics
#3
of 68 outputs
Altmetric has tracked 13,420,122 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,195 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 190,107 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.