↓ Skip to main content

Effect of intra-hippocampal injection of human recombinant growth hormone on synaptic plasticity in the nucleus basalis magnocellularis-lesioned aged rats

Overview of attention for article published in Arquivos de Neuro-Psiquiatria, July 2017
Altmetric Badge

Mentioned by

twitter
2 tweeters

Readers on

mendeley
8 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Effect of intra-hippocampal injection of human recombinant growth hormone on synaptic plasticity in the nucleus basalis magnocellularis-lesioned aged rats
Published in
Arquivos de Neuro-Psiquiatria, July 2017
DOI 10.1590/0004-282x20170074
Pubmed ID
Authors

Maryam Malek, Alireza Sarkaki, Saleh Zahedi-Asl, Yaghoob Farbood, Ziba Rajaei

Abstract

In this study, we proposed that administration of hippocampal growth hormone in ageing animals with growth hormone deficiency can compensate long-term potentiation and synaptic plasticity in nucleus basalis magnocellularis (NBM)-lesioned rats. Aged male Wistar rats were randomly divided into six groups (seven in each) of sham-operated healthy rats (Cont); NBM-lesioned rats (L); NBM-lesioned rats and intrahippocampal injection of growth hormone vehicle (L + Veh); NBM-lesioned and intrahippocampal injection of growth hormone (10, 20 and 40 µg.2 µl-1) (L + GH). In vivo electrophysiological recording techniques were used to characterize maintenance of long-term potentiation at distinct times (1, 2, 3, 24 and 48 hours) after high-frequency stimulation. The population spike was enhanced significantly for about 48 hours following tetanic stimulation in rats treated with a dose-dependent growth hormone compared to the vehicle group (p < 0.05), possibly through neuronal plasticity and neurogenesis in affected areas.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 2 25%
Student > Bachelor 2 25%
Student > Master 1 13%
Researcher 1 13%
Other 1 13%
Other 0 0%
Unknown 1 13%
Readers by discipline Count As %
Neuroscience 2 25%
Medicine and Dentistry 2 25%
Biochemistry, Genetics and Molecular Biology 1 13%
Pharmacology, Toxicology and Pharmaceutical Science 1 13%
Environmental Science 1 13%
Other 0 0%
Unknown 1 13%