Title |
Functional genomics annotation of a statistical epistasis network associated with bladder cancer susceptibility
|
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Published in |
BioData Mining, April 2014
|
DOI | 10.1186/1756-0381-7-5 |
Pubmed ID | |
Authors |
Ting Hu, Qinxin Pan, Angeline S Andrew, Jillian M Langer, Michael D Cole, Craig R Tomlinson, Margaret R Karagas, Jason H Moore |
Abstract |
Several different genetic and environmental factors have been identified as independent risk factors for bladder cancer in population-based studies. Recent studies have turned to understanding the role of gene-gene and gene-environment interactions in determining risk. We previously developed the bioinformatics framework of statistical epistasis networks (SEN) to characterize the global structure of interacting genetic factors associated with a particular disease or clinical outcome. By applying SEN to a population-based study of bladder cancer among Caucasians in New Hampshire, we were able to identify a set of connected genetic factors with strong and significant interaction effects on bladder cancer susceptibility. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Finland | 1 | 25% |
Spain | 1 | 25% |
United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Members of the public | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 25% |
Researcher | 8 | 25% |
Student > Master | 5 | 16% |
Student > Postgraduate | 3 | 9% |
Professor | 2 | 6% |
Other | 6 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 34% |
Biochemistry, Genetics and Molecular Biology | 7 | 22% |
Computer Science | 5 | 16% |
Medicine and Dentistry | 2 | 6% |
Mathematics | 1 | 3% |
Other | 4 | 13% |
Unknown | 2 | 6% |