Title |
Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin
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Published in |
Critical Care, April 2014
|
DOI | 10.1186/cc13830 |
Pubmed ID | |
Authors |
Holger C Müller-Redetzky, Daniel Will, Katharina Hellwig, Wolfgang Kummer, Thomas Tschernig, Uwe Pfeil, Renate Paddenberg, Michael D Menger, Olivia Kershaw, Achim D Gruber, Norbert Weissmann, Stefan Hippenstiel, Norbert Suttorp, Martin Witzenrath |
Abstract |
Ventilator-induced lung injury (VILI) contributes to morbidity and mortality in acute respiratory distress syndrome (ARDS). Particularly pre-injured lungs are susceptible to VILI despite protective ventilation. In a previous study, the endogenous peptide adrenomedullin (AM) protected murine lungs from VILI. We hypothesized that mechanical ventilation (MV) contributes to lung injury and sepsis in pneumonia, and that AM may reduce lung injury and multiple organ failure in ventilated mice with pneumococcal pneumonia. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 25% |
Italy | 1 | 13% |
Unknown | 5 | 63% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 63% |
Scientists | 1 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 2% |
Unknown | 54 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 18% |
Researcher | 8 | 15% |
Student > Master | 7 | 13% |
Student > Postgraduate | 6 | 11% |
Student > Bachelor | 4 | 7% |
Other | 6 | 11% |
Unknown | 14 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 24 | 44% |
Agricultural and Biological Sciences | 7 | 13% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Nursing and Health Professions | 2 | 4% |
Immunology and Microbiology | 2 | 4% |
Other | 4 | 7% |
Unknown | 13 | 24% |