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Altered activation state of circulating neutrophils in patients with neovascular age-related macular degeneration

Overview of attention for article published in Immunity & Ageing, July 2017
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  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

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2 tweeters
peer_reviews
1 peer review site

Citations

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15 Dimensions

Readers on

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31 Mendeley
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Title
Altered activation state of circulating neutrophils in patients with neovascular age-related macular degeneration
Published in
Immunity & Ageing, July 2017
DOI 10.1186/s12979-017-0100-9
Pubmed ID
Authors

Marie Krogh Nielsen, Sven Magnus Hector, Kelly Allen, Yousif Subhi, Torben Lykke Sørensen

Abstract

Neutrophil dysfunction plays a key role in the development of diseases characterized by inflammation and angiogenesis. Here, we studied the systemic expression of neutrophil markers reflecting activation, adhesion, and resolution of inflammation in patients with neovascular age-related macular degeneration (AMD). This was a prospective case-control study of patients with neovascular AMD and age-matched healthy control individuals. Patients were recruited from an outpatient program, and control individuals were recruited amongst patients' relatives. Current smokers and individuals with either active immune-disease or ongoing cancer were not included, as these factors are known to affect neutrophil function. Fresh-drawn venous blood was processed for flow cytometric analysis of neutrophil markers. We determined percentages of positive cells and compared expression levels using fluorescence intensity measures. We found conditional differences on marker expression between patients with neovascular AMD (n = 29) and controls (n = 28): no differences were found when looking broadly, but several differences emerged when focusing on non-smokers. Here, patients with neovascular AMD had increased expression of the activity marker cluster of differentiation (CD) 66b (P = 0.003; Mann-Whitney U test), decreased expression of adhesion marker CD162 (P = 0.044; Mann-Whitney U test), and lower expression of the resolution of inflammation marker C-X-C chemokine receptor 2 (P = 0.044; Mann-Whitney U test). We present novel evidence suggesting that the activity of circulating neutrophils, sensitive to smoking, may differ in patients with neovascular AMD.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 5 16%
Student > Ph. D. Student 5 16%
Researcher 5 16%
Student > Master 3 10%
Other 2 6%
Other 2 6%
Unknown 9 29%
Readers by discipline Count As %
Medicine and Dentistry 7 23%
Biochemistry, Genetics and Molecular Biology 6 19%
Agricultural and Biological Sciences 2 6%
Nursing and Health Professions 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 4 13%
Unknown 10 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2017.
All research outputs
#14,076,260
of 22,994,508 outputs
Outputs from Immunity & Ageing
#198
of 376 outputs
Outputs of similar age
#170,555
of 317,332 outputs
Outputs of similar age from Immunity & Ageing
#3
of 8 outputs
Altmetric has tracked 22,994,508 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 376 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.0. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,332 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.