Title |
Inflammatory cytokines in pulmonary hypertension
|
---|---|
Published in |
Respiratory Research, April 2014
|
DOI | 10.1186/1465-9921-15-47 |
Pubmed ID | |
Authors |
Alexandra Groth, Bart Vrugt, Matthias Brock, Rudolf Speich, Silvia Ulrich, Lars C Huber |
Abstract |
Pulmonary hypertension is an "umbrella term" used for a spectrum of entities resulting in an elevation of the pulmonary arterial pressure. Clinical symptoms include dyspnea and fatigue which in the absence of adequate therapeutic intervention may lead to progressive right heart failure and death. The pathogenesis of pulmonary hypertension is characterized by three major processes including vasoconstriction, vascular remodeling and microthrombotic events. In addition accumulating evidence point to a cytokine driven inflammatory process as a major contributor to the development of pulmonary hypertension.This review summarizes the latest clinical and experimental developments in inflammation associated with pulmonary hypertension with special focus on Interleukin-6, and its role in vascular remodeling in pulmonary hypertension. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 29% |
United Kingdom | 2 | 14% |
Chile | 1 | 7% |
Brazil | 1 | 7% |
Unknown | 6 | 43% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 14 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 1% |
Italy | 2 | 1% |
Brazil | 1 | <1% |
Unknown | 171 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 32 | 18% |
Researcher | 30 | 17% |
Student > Master | 17 | 10% |
Student > Bachelor | 16 | 9% |
Student > Doctoral Student | 14 | 8% |
Other | 33 | 19% |
Unknown | 34 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 60 | 34% |
Agricultural and Biological Sciences | 26 | 15% |
Biochemistry, Genetics and Molecular Biology | 26 | 15% |
Nursing and Health Professions | 3 | 2% |
Immunology and Microbiology | 3 | 2% |
Other | 16 | 9% |
Unknown | 42 | 24% |