Title |
Reduced immune cell infiltration and increased pro-inflammatory mediators in the brain of Type 2 diabetic mouse model infected with West Nile virus
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Published in |
Journal of Neuroinflammation, April 2014
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DOI | 10.1186/1742-2094-11-80 |
Pubmed ID | |
Authors |
Mukesh Kumar, Kelsey Roe, Pratibha V Nerurkar, Beverly Orillo, Karen S Thompson, Saguna Verma, Vivek R Nerurkar |
Abstract |
Diabetes is a significant risk factor for developing West Nile virus (WNV)-associated encephalitis (WNVE) in humans, the leading cause of arboviral encephalitis in the United States. Using a diabetic mouse model (db/db), we recently demonstrated that diabetes enhanced WNV replication and the susceptibility of mice to WNVE. Herein, we have examined immunological events in the brain of wild type (WT) and db/db mice after WNV infection. We hypothesized that WNV-induced migration of protective leukocytes into the brain is attenuated in the presence of diabetes, leading to a high viral load in the brain and severe disease in diabetic mice. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 60 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 8 | 13% |
Researcher | 7 | 12% |
Student > Ph. D. Student | 5 | 8% |
Other | 4 | 7% |
Unspecified | 4 | 7% |
Other | 10 | 17% |
Unknown | 22 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 17% |
Biochemistry, Genetics and Molecular Biology | 7 | 12% |
Immunology and Microbiology | 5 | 8% |
Unspecified | 4 | 7% |
Agricultural and Biological Sciences | 3 | 5% |
Other | 8 | 13% |
Unknown | 23 | 38% |