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Mendeley readers
Attention Score in Context
| Title |
Decidual NK cells regulate key developmental processes at the human fetal-maternal interface
|
|---|---|
| Published in |
Nature Medicine, August 2006
|
| DOI | 10.1038/nm1452 |
| Pubmed ID | |
| Authors |
Jacob Hanna, Debra Goldman-Wohl, Yaron Hamani, Inbal Avraham, Caryn Greenfield, Shira Natanson-Yaron, Diana Prus, Leonor Cohen-Daniel, Tal I Arnon, Irit Manaster, Roi Gazit, Vladimir Yutkin, Daniel Benharroch, Angel Porgador, Eli Keshet, Simcha Yagel, Ofer Mandelboim |
| Abstract |
Human CD56(bright) NK cells accumulate in the maternal decidua during pregnancy and are found in direct contact with fetal trophoblasts. Several mechanisms have been proposed to explain the inability of NK cells to kill the semiallogeneic fetal cells. However, the actual functions of decidual NK (dNK) cells during pregnancy are mostly unknown. Here we show that dNK cells, but not peripheral blood-derived NK subsets, regulate trophoblast invasion both in vitro and in vivo by production of the interleukin-8 and interferon-inducible protein-10 chemokines. Furthermore, dNK cells are potent secretors of an array of angiogenic factors and induce vascular growth in the decidua. Notably, such functions are regulated by specific interactions between dNK-activating and dNK-inhibitory receptors and their ligands, uniquely expressed at the fetal-maternal interface. The overall results support a 'peaceful' model for reproductive immunology, in which elements of innate immunity have been incorporated in a constructive manner to support reproductive tissue development. |
Mendeley readers
The data shown below were compiled from readership statistics for 658 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 1% |
| United Kingdom | 3 | <1% |
| France | 1 | <1% |
| Ireland | 1 | <1% |
| Turkey | 1 | <1% |
| South Africa | 1 | <1% |
| Israel | 1 | <1% |
| India | 1 | <1% |
| Netherlands | 1 | <1% |
| Other | 4 | <1% |
| Unknown | 636 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 124 | 19% |
| Student > Bachelor | 103 | 16% |
| Student > Master | 84 | 13% |
| Researcher | 81 | 12% |
| Student > Doctoral Student | 32 | 5% |
| Other | 79 | 12% |
| Unknown | 155 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 140 | 21% |
| Medicine and Dentistry | 118 | 18% |
| Biochemistry, Genetics and Molecular Biology | 100 | 15% |
| Immunology and Microbiology | 81 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 2% |
| Other | 41 | 6% |
| Unknown | 168 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2023.
All research outputs
#2,211,036
of 23,415,749 outputs
Outputs from Nature Medicine
#3,625
of 8,642 outputs
Outputs of similar age
#4,281
of 66,520 outputs
Outputs of similar age from Nature Medicine
#11
of 61 outputs
Altmetric has tracked 23,415,749 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,642 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 100.3. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 66,520 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.