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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Vascular measurements correlate with estrogen receptor status
|
|---|---|
| Published in |
BMC Cancer, April 2014
|
| DOI | 10.1186/1471-2407-14-279 |
| Pubmed ID | |
| Authors |
Mark C Lloyd, Khalid O Alfarouk, Daniel Verduzco, Marilyn M Bui, Robert J Gillies, Muntaser E Ibrahim, Joel S Brown, Robert A Gatenby |
| Abstract |
Breast carcinoma can be classified as either Estrogen Receptor (ER) positive or negative by immunohistochemical phenotyping, although ER expression may vary from 1 to 100% of malignant cells within an ER + tumor. This is similar to genetic variability observed in other tumor types and is generally viewed as a consequence of intratumoral evolution driven by random genetic mutations. Here we view cellular evolution within tumors as a classical Darwinian system in which variations in molecular properties represent predictable adaptations to spatially heterogeneous environmental selection forces. We hypothesize that ER expression is a successful adaptive strategy only if estrogen is present in the microenvironment. Since the dominant source of estrogen is blood flow, we hypothesized that, in general, intratumoral regions with higher blood flow would contain larger numbers of ER + cells when compared to areas of low blood flow and in turn necrosis. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 50% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 67% |
| Members of the public | 2 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 3% |
| Unknown | 31 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 41% |
| Researcher | 6 | 19% |
| Lecturer | 2 | 6% |
| Student > Doctoral Student | 2 | 6% |
| Other | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 4 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 25% |
| Medicine and Dentistry | 6 | 19% |
| Biochemistry, Genetics and Molecular Biology | 4 | 13% |
| Computer Science | 2 | 6% |
| Sports and Recreations | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 9 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 December 2015.
All research outputs
#7,133,038
of 22,754,104 outputs
Outputs from BMC Cancer
#1,919
of 8,275 outputs
Outputs of similar age
#69,990
of 227,083 outputs
Outputs of similar age from BMC Cancer
#36
of 138 outputs
Altmetric has tracked 22,754,104 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 8,275 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,083 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 138 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.