Title |
Accelerating the scoring module of mass spectrometry-based peptide identification using GPUs
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Published in |
BMC Bioinformatics, April 2014
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DOI | 10.1186/1471-2105-15-121 |
Pubmed ID | |
Authors |
You Li, Hao Chi, Leihao Xia, Xiaowen Chu |
Abstract |
Tandem mass spectrometry-based database searching is currently the main method for protein identification in shotgun proteomics. The explosive growth of protein and peptide databases, which is a result of genome translations, enzymatic digestions, and post-translational modifications (PTMs), is making computational efficiency in database searching a serious challenge. Profile analysis shows that most search engines spend 50%-90% of their total time on the scoring module, and that the spectrum dot product (SDP) based scoring module is the most widely used. As a general purpose and high performance parallel hardware, graphics processing units (GPUs) are promising platforms for speeding up database searches in the protein identification process. |
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Unknown | 2 | 67% |
Demographic breakdown
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
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Demographic breakdown
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Student > Ph. D. Student | 6 | 24% |
Researcher | 5 | 20% |
Student > Bachelor | 4 | 16% |
Professor > Associate Professor | 3 | 12% |
Student > Master | 3 | 12% |
Other | 4 | 16% |
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Other | 1 | 4% |