Title |
Deep Brain Stimulation for Disorders of Memory and Cognition
|
---|---|
Published in |
Neurotherapeutics, July 2014
|
DOI | 10.1007/s13311-014-0275-0 |
Pubmed ID | |
Authors |
Tejas Sankar, Nir Lipsman, Andres M. Lozano |
Abstract |
The next several decades will see an exponential rise in the number of patients with disorders of memory and cognition, and of Alzheimer's disease in particular. Impending demographic shifts, an absence of effective treatments, and the significant burden these conditions place on patients, caregivers, and society, mean there is an urgent need to develop novel therapies. Deep brain stimulation (DBS) is a neurosurgical procedure that is a standard-of-care for many patients with treatment-refractory Parkinson's disease, dystonia, and essential tremor. DBS has proven to be an effective means of modulating activity in disrupted motor circuitry, and has shown promise as a modulator of other dysfunctional circuits, including for mood and anxiety disorders. The deficits in Alzheimer's disease and other disorders of memory and cognition are also beginning to be thought of as arising from dysfunction in neural circuits. Such dysfunction may be amenable to modulation using focal brain stimulation. A global experience is now emerging for the use of DBS for these conditions, targeting key nodes in the memory circuit, including the fornix and nucleus basalis of Meynert. Such work holds promise as a novel therapeutic approach for one of medicine's most urgent priorities. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | <1% |
Unknown | 121 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 23 | 19% |
Student > Bachelor | 21 | 17% |
Student > Ph. D. Student | 20 | 16% |
Student > Master | 15 | 12% |
Student > Doctoral Student | 9 | 7% |
Other | 20 | 16% |
Unknown | 14 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 20% |
Neuroscience | 23 | 19% |
Psychology | 20 | 16% |
Agricultural and Biological Sciences | 11 | 9% |
Engineering | 7 | 6% |
Other | 10 | 8% |
Unknown | 26 | 21% |