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Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy

Overview of attention for article published in BMC Pregnancy and Childbirth, April 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
2 news outlets
blogs
2 blogs
twitter
29 X users
facebook
9 Facebook pages
googleplus
1 Google+ user
video
2 YouTube creators

Citations

dimensions_citation
54 Dimensions

Readers on

mendeley
173 Mendeley
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Title
Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy
Published in
BMC Pregnancy and Childbirth, April 2014
DOI 10.1186/1471-2393-14-150
Pubmed ID
Authors

Hayley Dickinson, Stacey Ellery, Zoe Ireland, Domenic LaRosa, Rodney Snow, David W Walker

Abstract

While the use of creatine in human pregnancy is yet to be fully evaluated, its long-term use in healthy adults appears to be safe, and its well documented neuroprotective properties have recently been extended by demonstrations that creatine improves cognitive function in normal and elderly people, and motor skills in sleep-deprived subjects. Creatine has many actions likely to benefit the fetus and newborn, because pregnancy is a state of heightened metabolic activity, and the placenta is a key source of free radicals of oxygen and nitrogen. The multiple benefits of supplementary creatine arise from the fact that the creatine-phosphocreatine [PCr] system has physiologically important roles that include maintenance of intracellular ATP and acid-base balance, post-ischaemic recovery of protein synthesis, cerebral vasodilation, antioxidant actions, and stabilisation of lipid membranes. In the brain, creatine not only reduces lipid peroxidation and improves cerebral perfusion, its interaction with the benzodiazepine site of the GABAA receptor is likely to counteract the effects of glutamate excitotoxicity - actions that may protect the preterm and term fetal brain from the effects of birth hypoxia. In this review we discuss the development of creatine synthesis during fetal life, the transfer of creatine from mother to fetus, and propose that creatine supplementation during pregnancy may have benefits for the fetus and neonate whenever oxidative stress or feto-placental hypoxia arise, as in cases of fetal growth restriction, premature birth, or when parturition is delayed or complicated by oxygen deprivation of the newborn.

X Demographics

X Demographics

The data shown below were collected from the profiles of 29 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 1%
United Kingdom 1 <1%
Bangladesh 1 <1%
United States 1 <1%
Unknown 168 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 31 18%
Student > Ph. D. Student 24 14%
Student > Bachelor 23 13%
Researcher 18 10%
Other 10 6%
Other 31 18%
Unknown 36 21%
Readers by discipline Count As %
Medicine and Dentistry 53 31%
Sports and Recreations 17 10%
Nursing and Health Professions 14 8%
Agricultural and Biological Sciences 12 7%
Biochemistry, Genetics and Molecular Biology 9 5%
Other 29 17%
Unknown 39 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 49. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2024.
All research outputs
#841,588
of 25,169,746 outputs
Outputs from BMC Pregnancy and Childbirth
#147
of 4,700 outputs
Outputs of similar age
#7,879
of 233,088 outputs
Outputs of similar age from BMC Pregnancy and Childbirth
#6
of 92 outputs
Altmetric has tracked 25,169,746 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,700 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,088 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.