Title |
Validation of quantitative magnetic resonance imaging-based apparent bone volume fraction in peri-articular tibial bone of cadaveric knees
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Published in |
BMC Musculoskeletal Disorders, April 2014
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DOI | 10.1186/1471-2474-15-143 |
Pubmed ID | |
Authors |
Jeffrey B Driban, Mary F Barbe, Mamta Amin, Neil S Kalariya, Ming Zhang, Grace H Lo, Anna M Tassinari, Daniel Harper, Lori Lyn Price, Charles B Eaton, Erika Schneider, Timothy E McAlindon |
Abstract |
In the knee, high-resolution magnetic resonance (MR) imaging has demonstrated that increased apparent bone volume fraction (trabecular bone volume per total volume; BV/TV) in the peri-articular proximal medial tibia is associated with joint space narrowing and the presence of bone marrow lesions. However, despite evidence of construct validity, MR-based apparent BV/TV has not yet been cross-validated in the proximal medial tibia by comparison with a gold standard (e.g., micro-computed tomography [microCT]). In this cadaveric validation study we explored the association between MR-based apparent BV/TV and microCT-based BV/TV in the proximal peri-articular medial tibia. |
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