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Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy

Overview of attention for article published in Journal of Hematology & Oncology, January 2017
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Mentioned by

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2 tweeters

Citations

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55 Dimensions

Readers on

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69 Mendeley
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Title
Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy
Published in
Journal of Hematology & Oncology, January 2017
DOI 10.1186/s13045-016-0373-z
Pubmed ID
Authors

Pablo Angulo, Gaurav Kaushik, Dharmalingam Subramaniam, Prasad Dandawate, Kathleen Neville, Katherine Chastain, Shrikant Anant

Abstract

Osteosarcoma is the most common primary bone cancer affecting children and adolescents worldwide. Despite an incidence of three cases per million annually, it accounts for an inordinate amount of morbidity and mortality. While the use of chemotherapy (cisplatin, doxorubicin, and methotrexate) in the last century initially resulted in marginal improvement in survival over surgery alone, survival has not improved further in the past four decades. Patients with metastatic osteosarcoma have an especially poor prognosis, with only 30% overall survival. Hence, there is a substantial need for new therapies. The inability to control the metastatic progression of this localized cancer stems from a lack of complete knowledge of the biology of osteosarcoma. Consequently, there has been an aggressive undertaking of scientific investigation of various signaling pathways that could be instrumental in understanding the pathogenesis of osteosarcoma. Here, we review these cancer signaling pathways, including Notch, Wnt, Hedgehog, phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT, and JAK/STAT, and their specific role in osteosarcoma. In addition, we highlight numerous natural compounds that have been documented to target these pathways effectively, including curcumin, diallyl trisulfide, resveratrol, apigenin, cyclopamine, and sulforaphane. We elucidate through references that these natural compounds can induce cancer signaling pathway manipulation and possibly facilitate new treatment modalities for osteosarcoma.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 68 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 20%
Student > Bachelor 11 16%
Researcher 11 16%
Student > Ph. D. Student 11 16%
Student > Postgraduate 5 7%
Other 12 17%
Unknown 5 7%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 21 30%
Medicine and Dentistry 15 22%
Agricultural and Biological Sciences 8 12%
Immunology and Microbiology 5 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 9 13%
Unknown 8 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2020.
All research outputs
#9,161,523
of 15,606,212 outputs
Outputs from Journal of Hematology & Oncology
#362
of 787 outputs
Outputs of similar age
#137,498
of 271,377 outputs
Outputs of similar age from Journal of Hematology & Oncology
#1
of 1 outputs
Altmetric has tracked 15,606,212 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 787 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,377 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them