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Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy

Overview of attention for article published in Journal of Hematology & Oncology, January 2017
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1 tweeter

Citations

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Title
Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy
Published in
Journal of Hematology & Oncology, January 2017
DOI 10.1186/s13045-016-0373-z
Pubmed ID
Authors

Pablo Angulo, Gaurav Kaushik, Dharmalingam Subramaniam, Prasad Dandawate, Kathleen Neville, Katherine Chastain, Shrikant Anant

Abstract

Osteosarcoma is the most common primary bone cancer affecting children and adolescents worldwide. Despite an incidence of three cases per million annually, it accounts for an inordinate amount of morbidity and mortality. While the use of chemotherapy (cisplatin, doxorubicin, and methotrexate) in the last century initially resulted in marginal improvement in survival over surgery alone, survival has not improved further in the past four decades. Patients with metastatic osteosarcoma have an especially poor prognosis, with only 30% overall survival. Hence, there is a substantial need for new therapies. The inability to control the metastatic progression of this localized cancer stems from a lack of complete knowledge of the biology of osteosarcoma. Consequently, there has been an aggressive undertaking of scientific investigation of various signaling pathways that could be instrumental in understanding the pathogenesis of osteosarcoma. Here, we review these cancer signaling pathways, including Notch, Wnt, Hedgehog, phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT, and JAK/STAT, and their specific role in osteosarcoma. In addition, we highlight numerous natural compounds that have been documented to target these pathways effectively, including curcumin, diallyl trisulfide, resveratrol, apigenin, cyclopamine, and sulforaphane. We elucidate through references that these natural compounds can induce cancer signaling pathway manipulation and possibly facilitate new treatment modalities for osteosarcoma.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 57 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 19%
Student > Ph. D. Student 11 19%
Student > Bachelor 9 16%
Researcher 8 14%
Student > Postgraduate 5 9%
Other 11 19%
Unknown 3 5%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 18 31%
Medicine and Dentistry 12 21%
Agricultural and Biological Sciences 8 14%
Immunology and Microbiology 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 7 12%
Unknown 6 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2017.
All research outputs
#9,231,584
of 11,536,085 outputs
Outputs from Journal of Hematology & Oncology
#334
of 498 outputs
Outputs of similar age
#193,101
of 263,286 outputs
Outputs of similar age from Journal of Hematology & Oncology
#6
of 7 outputs
Altmetric has tracked 11,536,085 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 498 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
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We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.