| Chapter title |
Neurobiological Mechanisms for Impulsive-Aggression: The Role of MAOA
|
|---|---|
| Chapter number | 272 |
| Book title |
Neuroscience of Aggression
|
| Published in |
Current topics in behavioral neurosciences, January 2014
|
| DOI | 10.1007/7854_2013_272 |
| Pubmed ID | |
| Book ISBNs |
978-3-66-244280-7, 978-3-66-244281-4
|
| Authors |
Hayley M. Dorfman, Andreas Meyer-Lindenberg, Joshua W. Buckholtz, Dorfman, Hayley M., Meyer-Lindenberg, Andreas, Buckholtz, Joshua W. |
| Abstract |
Aggression may be present across a large part of the spectrum of psychopathology, and underlies costly criminal antisocial behaviors. Human aggression is a complex and underspecified construct, confounding scientific discovery. Nevertheless, some biologically tractable subtypes are apparent, and one in particular-impulsive (reactive) aggression-appears to account for many facets of aggression-related dysfunction in psychiatric illness. Impulsive-aggression is significantly heritable, suggesting genetic transmission. However, the specific neurobiological mechanisms that mediate genetic risk for impulsive-aggression remain unclear. Here, we review extant data on the genetics and neurobiology of individual differences in impulsive-aggression, with particular attention to the role of genetic variation in Monoamine Oxidase A (MAOA) and its impact on serotonergic signaling within corticolimbic circuitry. |
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