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Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis

Overview of attention for article published in Journal of Neuroinflammation, July 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

blogs
1 blog
twitter
2 tweeters
googleplus
1 Google+ user

Citations

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6 Dimensions

Readers on

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19 Mendeley
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Title
Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis
Published in
Journal of Neuroinflammation, July 2017
DOI 10.1186/s12974-017-0926-2
Pubmed ID
Authors

Stolz, Leonie, Derouiche, Amin, Devraj, Kavi, Weber, Frank, Brunkhorst, Robert, Foerch, Christian, Leonie Stolz, Amin Derouiche, Kavi Devraj, Frank Weber, Robert Brunkhorst, Christian Foerch

Abstract

In multiple sclerosis, coagulation factors have been shown to modulate inflammation. In this translational study, we investigated whether long-term anticoagulation with warfarin or rivaroxaban has beneficial effects on the course of autoimmune experimental encephalomyelitis (EAE). Female SJL/J mice treated with anticoagulants namely warfarin or rivaroxaban were immunized with PLP139-151. Stable anticoagulation was maintained throughout the entire experiment. Mice without anticoagulation treated with the vehicle only were used as controls. The neurological deficit was recorded during the course of EAE, and histopathological analyses of inflammatory lesions were performed. In preventive settings, both treatment with warfarin and rivaroxaban reduced the maximum EAE score as compared to the control group and led to a reduction of inflammatory lesions in the spinal cord. In contrast, therapeutic treatment with warfarin had no beneficial effects on the clinical course of EAE. Signs of intraparenchymal hemorrhage at the site of the inflammatory lesions were not observed. We developed long-term anticoagulation models that allowed exploring the course of EAE under warfarin and rivaroxaban treatment. We found a mild preventive effect of both warfarin and rivaroxaban on neurological deficits and local inflammation, indicating a modulation of the disease induction by anticoagulation.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 26%
Student > Bachelor 3 16%
Researcher 3 16%
Other 2 11%
Student > Master 2 11%
Other 4 21%
Readers by discipline Count As %
Unspecified 6 32%
Medicine and Dentistry 6 32%
Neuroscience 4 21%
Agricultural and Biological Sciences 3 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2017.
All research outputs
#1,145,370
of 11,541,953 outputs
Outputs from Journal of Neuroinflammation
#127
of 1,309 outputs
Outputs of similar age
#44,752
of 263,358 outputs
Outputs of similar age from Journal of Neuroinflammation
#3
of 21 outputs
Altmetric has tracked 11,541,953 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,309 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,358 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.