Title |
Mammalian-wide interspersed repeat (MIR)-derived enhancers and the regulation of human gene expression
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Published in |
Mobile DNA, May 2014
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DOI | 10.1186/1759-8753-5-14 |
Pubmed ID | |
Authors |
Daudi Jjingo, Andrew B Conley, Jianrong Wang, Leonardo Mariño-Ramírez, Victoria V Lunyak, I King Jordan |
Abstract |
Mammalian-wide interspersed repeats (MIRs) are the most ancient family of transposable elements (TEs) in the human genome. The deep conservation of MIRs initially suggested the possibility that they had been exapted to play functional roles for their host genomes. MIRs also happen to be the only TEs whose presence in-and-around human genes is positively correlated to tissue-specific gene expression. Similar associations of enhancer prevalence within genes and tissue-specific expression, along with MIRs' previous implication as providing regulatory sequences, suggested a possible link between MIRs and enhancers. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 2 | 20% |
United Kingdom | 2 | 20% |
Japan | 2 | 20% |
United States | 1 | 10% |
Unknown | 3 | 30% |
Demographic breakdown
Type | Count | As % |
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Scientists | 6 | 60% |
Members of the public | 4 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 3 | 3% |
Netherlands | 1 | <1% |
Australia | 1 | <1% |
Unknown | 106 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 33 | 30% |
Student > Ph. D. Student | 22 | 20% |
Student > Master | 9 | 8% |
Student > Bachelor | 8 | 7% |
Student > Doctoral Student | 5 | 5% |
Other | 15 | 14% |
Unknown | 19 | 17% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 42 | 38% |
Biochemistry, Genetics and Molecular Biology | 34 | 31% |
Medicine and Dentistry | 4 | 4% |
Computer Science | 2 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | <1% |
Other | 4 | 4% |
Unknown | 24 | 22% |