Title |
Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden
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Published in |
BMC Cancer, May 2014
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DOI | 10.1186/1471-2407-14-317 |
Pubmed ID | |
Authors |
Khalid Abubaker, Rodney B Luwor, Hongjian Zhu, Orla McNally, Michael A Quinn, Christopher J Burns, Erik W Thompson, Jock K Findlay, Nuzhat Ahmed |
Abstract |
Current treatment of ovarian cancer patients with chemotherapy leaves behind a residual tumor which results in recurrent ovarian cancer within a short time frame. We have previously demonstrated that a single short-term treatment of ovarian cancer cells with chemotherapy in vitro resulted in a cancer stem cell (CSC)-like enriched residual population which generated significantly greater tumor burden compared to the tumor burden generated by control untreated cells. In this report we looked at the mechanisms of the enrichment of CSC-like residual cells in response to paclitaxel treatment. |
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Geographical breakdown
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Canada | 1 | 20% |
El Salvador | 1 | 20% |
United States | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 40% |
Practitioners (doctors, other healthcare professionals) | 2 | 40% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 2% |
Unknown | 82 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 19 | 23% |
Student > Ph. D. Student | 15 | 18% |
Student > Bachelor | 14 | 17% |
Student > Master | 11 | 13% |
Student > Postgraduate | 4 | 5% |
Other | 7 | 8% |
Unknown | 14 | 17% |
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Agricultural and Biological Sciences | 22 | 26% |
Biochemistry, Genetics and Molecular Biology | 20 | 24% |
Medicine and Dentistry | 10 | 12% |
Immunology and Microbiology | 3 | 4% |
Psychology | 2 | 2% |
Other | 8 | 10% |
Unknown | 19 | 23% |