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Attention Score in Context
| Title |
Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration
|
|---|---|
| Published in |
Nature Neuroscience, April 2008
|
| DOI | 10.1038/nn.2114 |
| Pubmed ID | |
| Authors |
Karun K Singh, Katya J Park, Elizabeth J Hong, Bianca M Kramer, Michael E Greenberg, David R Kaplan, Freda D Miller |
| Abstract |
The mechanisms that regulate the pruning of mammalian axons are just now being elucidated. Here, we describe a mechanism by which, during developmental sympathetic axon competition, winning axons secrete brain-derived neurotrophic factor (BDNF) in an activity-dependent fashion, which binds to the p75 neurotrophin receptor (p75NTR) on losing axons to cause their degeneration and, ultimately, axon pruning. Specifically, we found that pruning of rat and mouse sympathetic axons that project to the eye requires both activity-dependent BDNF and p75NTR. p75NTR and BDNF are also essential for activity-dependent axon pruning in culture, where they mediate pruning by directly causing axon degeneration. p75NTR, which is enriched in losing axons, causes axonal degeneration by suppressing TrkA-mediated signaling that is essential for axonal maintenance. These data provide a mechanism that explains how active axons can eliminate less-active, competing axons during developmental pruning by directly promoting p75NTR-mediated axonal degeneration. |
Mendeley readers
The data shown below were compiled from readership statistics for 198 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 3% |
| Canada | 2 | 1% |
| France | 1 | <1% |
| United Kingdom | 1 | <1% |
| Austria | 1 | <1% |
| Japan | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 186 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 56 | 28% |
| Student > Ph. D. Student | 44 | 22% |
| Professor > Associate Professor | 16 | 8% |
| Student > Master | 15 | 8% |
| Professor | 14 | 7% |
| Other | 30 | 15% |
| Unknown | 23 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 95 | 48% |
| Neuroscience | 40 | 20% |
| Medicine and Dentistry | 15 | 8% |
| Biochemistry, Genetics and Molecular Biology | 13 | 7% |
| Psychology | 7 | 4% |
| Other | 3 | 2% |
| Unknown | 25 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2011.
All research outputs
#17,932,284
of 26,017,215 outputs
Outputs from Nature Neuroscience
#5,097
of 5,702 outputs
Outputs of similar age
#86,555
of 99,950 outputs
Outputs of similar age from Nature Neuroscience
#46
of 54 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,702 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 57.9. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 99,950 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.